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Study · Animal study (in vivo) · mouse · 2014

2 results

Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.

Liu W, Zhai X, Li H, Ji L

Journal of affective disorders17 Dec 2013Cited by 33 (Europe PMC)

PMID24388462 (opens in a new tab)DOI10.1016/j.jad.2013.11.025 (opens in a new tab)PepBankPUB-24388462
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In depression-like and insulin-resistant mice, AICAR showed potential chronic antidepressant action.

    In plain wordsIn mice, AICAR showed potential for a lasting antidepressant effect.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseDepression-like behavior
    Study

    mousen: not reported in source

    high-fat diet and corticosterone-induced depression-like and insulin-resistant mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, our results show a clear potential for AICAR as a putative antidepressant with a chronic action on the DIR mice.
    1 context sentence
    Summary · context
    Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with long-term high-fat feeding, AICAR avoided reducing skeletal muscle insulin action, unlike traditional antidepressants.

    In plain wordsIn mice, AICAR avoided reducing muscle insulin action during long-term high-fat feeding, unlike traditional antidepressants.

    Peptide
    AICAR (acadesine)
    Outcome
    No significant changeSkeletal muscle insulin action
    Study

    mousen: not reported in source

    high-fat diet and corticosterone-induced depression-like and insulin-resistant mice
    Comparator
    traditional antidepressants
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to the traditional antidepressants, AICAR as a promising antidepressant avoids reducing insulin actions of skeletal muscle in the context of long-term HFD.
    1 context sentence
    Summary · context
    Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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