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Study · Animal study (in vivo) · rat · 2013

8 results

Caudal fourth ventricular administration of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside regulates glucose and counterregulatory hormone profiles, dorsal vagal complex metabolosensory neuron function, and hypothalamic Fos expression.

Ibrahim BA, Tamrakar P, Gujar AD, Cherian AK, Briski KP

Journal of neuroscience research3 Jul 2013Cited by 27 (Europe PMC)

PMID23825033 (opens in a new tab)DOI10.1002/jnr.23230 (opens in a new tab)PepBankPUB-23825033
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR caused site-specific changes in hypothalamic Fos immunolabeling in paraventricular, ventromedial, and arcuate nuclei.

    In plain wordsIn rats, AICAR changed Fos labeling in several hypothalamic regions, with no direction specified.

    Peptide
    AICAR (acadesine)
    Outcome
    Direction not reportedHypothalamic Fos immunolabeling
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · caudal fourth ventricularAs given in this study (rat).

    Source sentences

    Summary
    CV4 AICAR also resulted in site-specific modifications in Fos immunolabeling of hypothalamic metabolic structures, including the paraventricular, ventromedial, and arcuate nuclei.
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

Studies that did not test the peptide alone7

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, estradiol advanced AICAR-induced increases in A2 neuron phospho-AMPK expression.

    In plain wordsIn rats, estradiol advanced the AICAR-induced increase in A2 neuron phospho-AMPK expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseA2 phospho-AMPK expression
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    E advanced AICAR-induced increases in A2 phospho-AMPK (pAMPK) expression and in blood glucose levels
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, estradiol advanced AICAR-induced increases in blood glucose.

    In plain wordsIn rats, estradiol advanced the AICAR-induced increase in blood glucose.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBlood glucose
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    E advanced AICAR-induced increases in A2 phospho-AMPK (pAMPK) expression and in blood glucose levels
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR increased A2 neuron Fos protein only with estradiol support.

    In plain wordsIn rats, AICAR increased A2 neuron Fos protein only with estradiol support.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseA2 neuron Fos protein
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    was required for augmentation of Fos, estrogen receptor-α (ERα), monocarboxylate transporter-2, and glucose transporter-3 protein in A2 neurons and enhancement of corticosterone secretion by this treatment paradigm.
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR increased A2 neuron estrogen receptor-α protein only with estradiol support.

    In plain wordsIn rats, AICAR increased A2 neuron estrogen receptor-α protein only with estradiol support.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseA2 neuron estrogen receptor-α protein
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    was required for augmentation of Fos, estrogen receptor-α (ERα), monocarboxylate transporter-2, and glucose transporter-3 protein in A2 neurons and enhancement of corticosterone secretion by this treatment paradigm.
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  5. 06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR increased A2 monocarboxylate transporter-2 protein only with estradiol support.

    In plain wordsIn rats, AICAR increased A2 monocarboxylate transporter-2 protein only with estradiol support.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseA2 monocarboxylate transporter-2 protein
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    was required for augmentation of Fos, estrogen receptor-α (ERα), monocarboxylate transporter-2, and glucose transporter-3 protein in A2 neurons and enhancement of corticosterone secretion by this treatment paradigm.
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  6. 07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR increased A2 glucose transporter-3 protein only with estradiol support.

    In plain wordsIn rats, AICAR increased A2 glucose transporter-3 protein only with estradiol support.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseA2 glucose transporter-3 protein
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    was required for augmentation of Fos, estrogen receptor-α (ERα), monocarboxylate transporter-2, and glucose transporter-3 protein in A2 neurons and enhancement of corticosterone secretion by this treatment paradigm.
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  7. 08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, AICAR enhanced corticosterone secretion only with estradiol support.

    In plain wordsIn rats, AICAR increased corticosterone secretion only with estradiol support.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCorticosterone secretion
    Study

    ratn: not reported in source

    Estradiol- or oil-implanted ovariectomized female rats
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    was required for augmentation of Fos, estrogen receptor-α (ERα), monocarboxylate transporter-2, and glucose transporter-3 protein in A2 neurons and enhancement of corticosterone secretion by this treatment paradigm.
    1 context sentence
    Summary · context
    Dorsal vagal complex A2 noradrenergic neurons were laser microdissected from estradiol benzoate (E)- or oil (O)-implanted ovariectomized female rats after caudal fourth ventricular (CV4) delivery of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside (AICAR), for Western blot analysis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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