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Study · Animal study (in vivo) · mouse · 2019

4 results

AMPK activation attenuates inflammatory response to reduce ambient PM2.5-induced metabolic disorders in healthy and diabetic mice.

Pan K, Jiang S, Du X, Zeng X, Zhang J, Song L, Zhou J, Kan H, Sun Q, Xie Y, Zhao J

Ecotoxicology and environmental safety6 May 2019Cited by 41 (Europe PMC)

PMID31071567 (opens in a new tab)DOI10.1016/j.ecoenv.2019.04.038 (opens in a new tab)PepBankPUB-31071567
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, AICAR significantly enhanced energy metabolism.

    In plain wordsIn mice exposed to fine particulate matter, AICAR increased energy metabolism.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseEnergy metabolism
    Study

    mousen: not reported in source

    PM2.5-exposed C57BL/6 and db/db mice
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    More importantly, AICAR administration led to the significant enhancement of energy metabolism, elevation of AMPK as well as the decreased IL-6 and TNF-α in VAT of PM2.5-exposed mice
    2 context sentences
    Summary · context
    In this study, C57BL/6 and db/db mice were exposed to concentrated PM2.5 or filtered air using Shanghai Meteorological and Environmental Animal Exposure System (Shanghai-METAS) for 12 weeks.
    Summary · context
    From week 11, some of the mice were assigned to receive a subcutaneous injection of AMPK activator (AICAR).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, AICAR elevated AMPK.

    In plain wordsIn mice exposed to fine particulate matter, AICAR increased AMPK.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK elevation
    Study

    mousen: not reported in source

    PM2.5-exposed C57BL/6 and db/db mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    More importantly, AICAR administration led to the significant enhancement of energy metabolism, elevation of AMPK as well as the decreased IL-6 and TNF-α in VAT of PM2.5-exposed mice
    2 context sentences
    Summary · context
    In this study, C57BL/6 and db/db mice were exposed to concentrated PM2.5 or filtered air using Shanghai Meteorological and Environmental Animal Exposure System (Shanghai-METAS) for 12 weeks.
    Summary · context
    From week 11, some of the mice were assigned to receive a subcutaneous injection of AMPK activator (AICAR).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, AICAR decreased IL-6 in visceral adipose tissue.

    In plain wordsIn mice exposed to fine particulate matter, AICAR reduced IL-6 in visceral fat.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseVAT IL-6
    Study

    mousen: not reported in source

    PM2.5-exposed C57BL/6 and db/db mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    More importantly, AICAR administration led to the significant enhancement of energy metabolism, elevation of AMPK as well as the decreased IL-6 and TNF-α in VAT of PM2.5-exposed mice
    2 context sentences
    Summary · context
    In this study, C57BL/6 and db/db mice were exposed to concentrated PM2.5 or filtered air using Shanghai Meteorological and Environmental Animal Exposure System (Shanghai-METAS) for 12 weeks.
    Summary · context
    From week 11, some of the mice were assigned to receive a subcutaneous injection of AMPK activator (AICAR).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In PM-exposed mice, AICAR decreased TNF-α in visceral adipose tissue.

    In plain wordsIn mice exposed to fine particulate matter, AICAR reduced TNF-α in visceral fat.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseVAT TNF-α
    Study

    mousen: not reported in source

    PM2.5-exposed C57BL/6 and db/db mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    More importantly, AICAR administration led to the significant enhancement of energy metabolism, elevation of AMPK as well as the decreased IL-6 and TNF-α in VAT of PM2.5-exposed mice
    2 context sentences
    Summary · context
    In this study, C57BL/6 and db/db mice were exposed to concentrated PM2.5 or filtered air using Shanghai Meteorological and Environmental Animal Exposure System (Shanghai-METAS) for 12 weeks.
    Summary · context
    From week 11, some of the mice were assigned to receive a subcutaneous injection of AMPK activator (AICAR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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