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Study · Animal study (in vivo) · rat · 2015

13 results

AICAR attenuates organ injury and inflammatory response after intestinal ischemia and reperfusion.

Idrovo JP, Yang WL, Jacob A, Aziz M, Nicastro J, Coppa GF, Wang P

Molecular medicine (Cambridge, Mass.)19 Mar 2015Cited by 21 (Europe PMC)

PMID25611433 (opens in a new tab)PMCIDPMC4398665 (opens in a new tab)DOI10.2119/molmed.2014.00134 (opens in a new tab)PepBankPUB-25611433
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Summary

Intestinal ischemia and reperfusion (I/R) is encountered in various clinical conditions and contributes to multiorgan failure and mortality as high as 60% to 80%. Intestinal I/R not only injures the intestine, but affects remote organs such as the lung leading to acute lung injury. The development of novel and effective therapies for intestinal I/R are critical for the improvement of patient outcome. AICAR (5-aminoimidazole-4-carboxyamide ribonucleoside) is a cell-permeable compound that has been shown to possess antiinflammatory effects. The objective is to determine that treatment with AICAR attenuates intestinal I/R injury and subsequent acute lung injury (ALI). Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion. At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min. At 4 h after reperfusion, blood and tissues were collected for further analyses. Treatment with AICAR significantly decreased the gut damage score and the water content, indicating improvement in histological integrity. The treatment also attenuated tissue injury and proinflammatory cytokines, and reduced bacterial translocation to the gut. AICAR administration after intestinal I/R maintained lung integrity, attenuated neutrophil chemotaxis and infiltration to the lungs and decreased lung levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Inflammatory mediators, lung-inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, were decreased in the lungs and lung apoptosis was significantly reduced after AICAR treatment. These data indicate that AICAR could be developed as an effective and novel therapeutic for intestinal I/R and subsequent ALI.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR decreased the gut damage score versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced the gut damage score versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseGut damage score
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    Treatment with AICAR significantly decreased the gut damage score and the water content, indicating improvement in histological integrity.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR decreased gut water content versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced gut water content versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseGut water content
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    Treatment with AICAR significantly decreased the gut damage score and the water content, indicating improvement in histological integrity.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR attenuated tissue injury versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced tissue damage versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTissue injury
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    The treatment also attenuated tissue injury and proinflammatory cytokines, and reduced bacterial translocation to the gut.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR attenuated proinflammatory cytokines versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced inflammatory signals versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseProinflammatory cytokines
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    The treatment also attenuated tissue injury and proinflammatory cytokines, and reduced bacterial translocation to the gut.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR reduced bacterial translocation to the gut versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced bacterial movement to the gut versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseBacterial translocation
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Infection and antimicrobial activity · Gastrointestinal
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    The treatment also attenuated tissue injury and proinflammatory cytokines, and reduced bacterial translocation to the gut.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR maintained lung integrity versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR preserved lung structure versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseLung integrity
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    AICAR administration after intestinal I/R maintained lung integrity, attenuated neutrophil chemotaxis and infiltration to the lungs and decreased lung levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR attenuated neutrophil chemotaxis to the lungs versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced immune-cell attraction to the lungs versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNeutrophil chemotaxis
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Immune response · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    AICAR administration after intestinal I/R maintained lung integrity, attenuated neutrophil chemotaxis and infiltration to the lungs and decreased lung levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR attenuated lung neutrophil infiltration versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced immune-cell entry into the lungs versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung neutrophil infiltration
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Immune response · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    AICAR administration after intestinal I/R maintained lung integrity, attenuated neutrophil chemotaxis and infiltration to the lungs and decreased lung levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR decreased lung TNF-alpha versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced lung TNF-alpha versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung TNF-alpha
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    AICAR administration after intestinal I/R maintained lung integrity, attenuated neutrophil chemotaxis and infiltration to the lungs and decreased lung levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR decreased lung IL-6 versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced lung IL-6 versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung IL-6
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    AICAR administration after intestinal I/R maintained lung integrity, attenuated neutrophil chemotaxis and infiltration to the lungs and decreased lung levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR decreased lung iNOS protein versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced lung iNOS protein versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung iNOS protein
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    Inflammatory mediators, lung-inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, were decreased in the lungs and lung apoptosis was significantly reduced after AICAR treatment.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR decreased lung COX-2 protein versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced lung COX-2 protein versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung COX-2 protein
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    Inflammatory mediators, lung-inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, were decreased in the lungs and lung apoptosis was significantly reduced after AICAR treatment.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intestinal ischemia/reperfusion, AICAR reduced lung apoptosis versus vehicle.

    In plain wordsIn rats with intestinal injury, AICAR reduced lung cell death versus vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung apoptosis
    Study

    ratn: not reported in source

    Intestinal ischemia/reperfusion in male Sprague Dawley rats
    Comparator
    Vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    30 mg/kg BW · intravenous · 30 minAs given in this study (rat).

    Source sentences

    Summary
    Inflammatory mediators, lung-inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins, were decreased in the lungs and lung apoptosis was significantly reduced after AICAR treatment.
    3 context sentences
    Summary · context
    Male Sprague Dawley rats (275 to 325 g) underwent intestinal I/R injury with blockage of the superior mesenteric artery for 90 min and subsequent reperfusion.
    Summary · context
    At the initiation of reperfusion, vehicle or AICAR (30 mg/kg BW) was given intravenously (IV) for 30 min.
    Summary · context
    At 4 h after reperfusion, blood and tissues were collected for further analyses.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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