Skip to content

Study · Animal study (in vivo) · mouse · 2018

8 results

Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.

Singh I, Samuvel DJ, Choi S, Saxena N, Singh AK, Won J

Immunology8 Feb 2018Cited by 24 (Europe PMC)

PMID29331024 (opens in a new tab)DOI10.1111/imm.12893 (opens in a new tab)PepBankPUB-29331024
Source linkPubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, AICAR alone partially attenuated clinical disease.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, AICAR alone partly reduced clinical disease.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseClinical disease with AICAR alone
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We observed that lovastatin and AICAR treatments individually provided partial protection of mitochondria/peroxisomes and myelin/axons, and therefore partial attenuation of clinical disease in EAE mice.
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In EAE mice, adding AICAR to lovastatin improved clinical disease more than lovastatin alone.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, AICAR plus lovastatin improved clinical disease more than lovastatin alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseClinical disease versus lovastatin
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Comparator
    Lovastatin alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · oralAs given in this study (mouse).

    Source sentences

    Summary
    However, treatment of EAE mice with the lovastatin and AICAR combination provided greater protection of mitochondria/peroxisomes and myelin/axons, and greater improvement in clinical disease compared with individual drug treatments.
    2 context sentences
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…
    Summary · context
    oral medication with a combination of lovastatin and AICAR
  3. 03AnimalAnimal study (in vivo)Mechanism

    In EAE mouse spinal cords, AICAR activated AMPK.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, AICAR activated AMPK in the spinal cord.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAMPK activation
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In spinal cords of EAE mice, lovastatin-mediated inhibition of RhoA and AICAR-mediated activation of AMPK cooperatively enhanced the expression of the transcription factors and regulators (e.g. PPARα/β, SIRT-1, NRF-1, and TFAM) required for biogenesis and the functions of mitochondria (e.g. OXPHOS,…
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…

Studies that did not test the peptide alone5

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 04AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In EAE mice, lovastatin plus AICAR improved clinical disease more than AICAR alone.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, lovastatin plus AICAR improved clinical disease more than AICAR alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseClinical disease versus AICAR
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Comparator
    AICAR alone
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    However, treatment of EAE mice with the lovastatin and AICAR combination provided greater protection of mitochondria/peroxisomes and myelin/axons, and greater improvement in clinical disease compared with individual drug treatments.
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 05AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In EAE mouse spinal cords, lovastatin and AICAR cooperatively enhanced PPARα/β expression.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, lovastatin and AICAR together increased spinal PPARα/β expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePPARα/β expression
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In spinal cords of EAE mice, lovastatin-mediated inhibition of RhoA and AICAR-mediated activation of AMPK cooperatively enhanced the expression of the transcription factors and regulators (e.g. PPARα/β, SIRT-1, NRF-1, and TFAM) required for biogenesis and the functions of mitochondria (e.g. OXPHOS,…
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  3. 06AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In EAE mouse spinal cords, lovastatin and AICAR cooperatively enhanced SIRT-1 expression.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, lovastatin and AICAR together increased spinal SIRT-1 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSIRT-1 expression
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In spinal cords of EAE mice, lovastatin-mediated inhibition of RhoA and AICAR-mediated activation of AMPK cooperatively enhanced the expression of the transcription factors and regulators (e.g. PPARα/β, SIRT-1, NRF-1, and TFAM) required for biogenesis and the functions of mitochondria (e.g. OXPHOS,…
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  4. 07AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In EAE mouse spinal cords, lovastatin and AICAR cooperatively enhanced NRF-1 expression.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, lovastatin and AICAR together increased spinal NRF-1 expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseNRF-1 expression
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In spinal cords of EAE mice, lovastatin-mediated inhibition of RhoA and AICAR-mediated activation of AMPK cooperatively enhanced the expression of the transcription factors and regulators (e.g. PPARα/β, SIRT-1, NRF-1, and TFAM) required for biogenesis and the functions of mitochondria (e.g. OXPHOS,…
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  5. 08AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In EAE mouse spinal cords, lovastatin and AICAR cooperatively enhanced TFAM expression.

    In plain wordsIn mice with experimental autoimmune encephalomyelitis, lovastatin and AICAR together increased spinal TFAM expression.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseTFAM expression
    Study

    mousen: not reported in source

    Experimental autoimmune encephalomyelitis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In spinal cords of EAE mice, lovastatin-mediated inhibition of RhoA and AICAR-mediated activation of AMPK cooperatively enhanced the expression of the transcription factors and regulators (e.g. PPARα/β, SIRT-1, NRF-1, and TFAM) required for biogenesis and the functions of mitochondria (e.g. OXPHOS,…
    1 context sentence
    Summary · context
    In this study, we investigated the efficacy of a combination of lovastatin and AMP-activated protein kinase (AMPK) activator (AICAR) on the loss and dysfunction of mitochondria and peroxisomes and myelin and axonal damage in spinal cords, relative to the clinical disease symptoms, using a mouse mode…

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.