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Study · Animal study (in vivo) · rat · 2006

7 results

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.

Prasad R, Giri S, Nath N, Singh I, Singh AK

Journal of neuroscience research1 Aug 2006Cited by 53 (Europe PMC)

PMID16770773 (opens in a new tab)DOI10.1002/jnr.20953 (opens in a new tab)PepBankPUB-16770773
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, AICAR lowered clinical scores versus untreated EAE animals.

    In plain wordsIn rats with EAE, AICAR lowered disease scores versus untreated animals.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseClinical score
    Study

    ratn: not reported in source

    acute experimental autoimmune encephalomyelitis
    Comparator
    untreated EAE animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By maintaining the blood-brain barrier (BBB), AICAR-administered animals showed lower clinical scores compared with untreated EAE animals.
    1 context sentence
    Summary · context
    Here we used a rat model of acute EAE to show antiinflammatory effects of AICAR after daily treatment starting at onset of the disease.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with acute EAE, AICAR maintained the blood-brain barrier versus untreated EAE animals.

    In plain wordsIn rats with EAE, AICAR preserved the brain barrier versus untreated animals.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseBlood-brain barrier maintenance
    Study

    ratn: not reported in source

    acute experimental autoimmune encephalomyelitis
    Comparator
    untreated EAE animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By maintaining the blood-brain barrier (BBB), AICAR-administered animals showed lower clinical scores compared with untreated EAE animals.
    1 context sentence
    Summary · context
    Here we used a rat model of acute EAE to show antiinflammatory effects of AICAR after daily treatment starting at onset of the disease.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with EAE, AICAR inhibited inflammatory cell infiltration across the blood-brain barrier.

    In plain wordsIn rats with EAE, AICAR reduced inflammatory cell entry across the brain barrier compared with untreated EAE animals.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInflammatory cell infiltration
    Study

    ratn: not reported in source

    acute experimental autoimmune encephalomyelitis
    Comparator
    untreated EAE animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR inhibited the infiltration of inflammatory cells across the BBB, resulting in lowered expression of proinflammatory mediators in the CNS and protection from severe demyelination.
    1 context sentence
    Summary · context
    Here we used a rat model of acute EAE to show antiinflammatory effects of AICAR after daily treatment starting at onset of the disease.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with EAE, AICAR lowered CNS proinflammatory mediator expression.

    In plain wordsIn rats with EAE, AICAR reduced central nervous system inflammatory signals compared with untreated EAE animals.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseProinflammatory mediator expression
    Study

    ratn: not reported in source

    acute experimental autoimmune encephalomyelitis
    Comparator
    untreated EAE animals
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR inhibited the infiltration of inflammatory cells across the BBB, resulting in lowered expression of proinflammatory mediators in the CNS and protection from severe demyelination.
    1 context sentence
    Summary · context
    Here we used a rat model of acute EAE to show antiinflammatory effects of AICAR after daily treatment starting at onset of the disease.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with EAE, AICAR protected against severe demyelination.

    In plain wordsIn rats with EAE, AICAR protected against severe loss of nerve insulation compared with untreated EAE animals.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseDemyelination
    Study

    ratn: not reported in source

    acute experimental autoimmune encephalomyelitis
    Comparator
    untreated EAE animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR inhibited the infiltration of inflammatory cells across the BBB, resulting in lowered expression of proinflammatory mediators in the CNS and protection from severe demyelination.
    1 context sentence
    Summary · context
    Here we used a rat model of acute EAE to show antiinflammatory effects of AICAR after daily treatment starting at onset of the disease.
  6. 06LabIn vitro (cells)Efficacy outcome

    In an endothelial-leukocyte model, AICAR inhibited monocyte adhesion to TNF-alpha-activated endothelial cells.

    In plain wordsIn lab tests, AICAR reduced monocyte attachment to activated blood vessel cells.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMonocyte adhesion
    Study

    n: not reported in source

    endothelial-leukocyte interaction model
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By using in vitro model of endothelial-leukocyte interaction, we showed that AICAR inhibited adhesion of monocytes to tumor necrosis factor-alpha-activated endothelial cells.
  7. 07LabIn vitro (cells)Mechanism

    In an endothelial-leukocyte model, AICAR downregulated endothelial adhesion molecules through modulation of nuclear factor kappaB activation.

    In plain wordsIn lab tests, AICAR reduced cell adhesion molecule expression through changes in nuclear factor kappaB activation.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseEndothelial adhesion molecule expression
    Study

    n: not reported in source

    endothelial-leukocyte interaction model
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    One of the mechanisms of this action is through down-regulation of expression of endothelial cell adhesion molecules via modulation of nuclear factor kappaB activation.
    1 context sentence
    Summary · context
    By using in vitro model of endothelial-leukocyte interaction, we showed that AICAR inhibited adhesion of monocytes to tumor necrosis factor-alpha-activated endothelial cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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