Study · Animal study (in vivo) · mouse · 2004
3 resultsHolmes BF, Lang DB, Birnbaum MJ, Mu J, Dohm GL
American journal of physiology. Endocrinology and metabolism27 May 2004Cited by 49 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
2 results from studies that gave the peptide. No result from this study comes from people.
In mouse innervated muscle, AICAR treatment increased GLUT4 mRNA.
In plain wordsIn mice, AICAR increased GLUT4 mRNA in muscle with intact nerves.
mousen: not reported in source
mouse skeletal muscleSource sentences
GLUT4 mRNA was also increased by AICAR treatment in both the innervated and denervated muscles.
In mouse denervated muscle, AICAR treatment increased GLUT4 mRNA.
In plain wordsIn mice, AICAR increased GLUT4 mRNA in muscle without its nerve supply.
mousen: not reported in source
mouse skeletal muscleSource sentences
GLUT4 mRNA was also increased by AICAR treatment in both the innervated and denervated muscles.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).
In transgenic AMPK-DN mice, GLUT4 did not increase after AICAR treatment.
In plain wordsIn genetically changed mice, AICAR did not increase muscle GLUT4.
mousen: not reported in source
mouse skeletal muscleSource sentences
GLUT4 did not increase in AMPK-DN mice that were treated with AICAR, demonstrating that muscle AMPK is inactive.
To investigate the role of AMPK in GLUT4 regulation in response to exercise and denervation, transgenic mice with a mutated AMPK alpha-subunit (dominant negative; AMPK-DN) were studied.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
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Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC
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