5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions.

Gaskin FS, Kamada K, Yusof M, Korthuis RJ

American journal of physiology. Heart and circulatory physiology25 Aug 2006Cited by 41 (Europe PMC)

PMID16935999DOI10.1152/ajpheart.00744.2006PepBankPUB-16935999

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In wild-type mice, late AICAR preconditioning prevented postischemic leukocyte rolling.
In plain wordsIn mice, AICAR given before ischemia reduced leukocyte rolling compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
DecreaseLate preconditioning leukocyte rolling in WT
Study
mousen: not reported in source
Wild-type mice with jejunal ischemia-reperfusion
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 24 h before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC prevented postischemic LR and LA, whereas early AICAR PC prevented LA in WT mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599901
02AnimalAnimal study (in vivo)Efficacy outcome
In wild-type mice, late AICAR preconditioning prevented postischemic stationary leukocyte adhesion.
In plain wordsIn mice, late AICAR treatment reduced leukocyte adhesion compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
DecreaseLate preconditioning leukocyte adhesion in WT
Study
mousen: not reported in source
Wild-type mice with jejunal ischemia-reperfusion
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 24 h before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC prevented postischemic LR and LA, whereas early AICAR PC prevented LA in WT mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599902
03AnimalAnimal study (in vivo)Efficacy outcome
In wild-type mice, early AICAR preconditioning prevented postischemic leukocyte adhesion.
In plain wordsIn mice, early AICAR treatment reduced leukocyte adhesion compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
DecreaseEarly preconditioning leukocyte adhesion in WT
Study
mousen: not reported in source
Wild-type mice with jejunal ischemia-reperfusion
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 30 min before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC prevented postischemic LR and LA, whereas early AICAR PC prevented LA in WT mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599903
04AnimalAnimal study (in vivo)Efficacy outcome
In eNOS-deficient mice, late AICAR preconditioning did not prevent postischemic leukocyte rolling.
In plain wordsIn mice without eNOS, late AICAR treatment did not prevent leukocyte rolling compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
No significant changeLate preconditioning leukocyte rolling in eNOS knockout
Study
mousen: not reported in source
eNOS knockout mice with jejunal ischemia-reperfusion
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 24 h before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC was ineffective in preventing I/R-induced LR but not LA in the eNOS(-/-) mice, and the same pattern was seen in WT animals treated with the NOS inhibitor N(omega)-nitro-l-arginine.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599904
05AnimalAnimal study (in vivo)Efficacy outcome
In eNOS-deficient mice, late AICAR preconditioning prevented postischemic leukocyte adhesion.
In plain wordsIn mice without eNOS, late AICAR treatment reduced leukocyte adhesion compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
DecreaseLate preconditioning leukocyte adhesion in eNOS knockout
Study
mousen: not reported in source
eNOS knockout mice with jejunal ischemia-reperfusion
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 24 h before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC was ineffective in preventing I/R-induced LR but not LA in the eNOS(-/-) mice, and the same pattern was seen in WT animals treated with the NOS inhibitor N(omega)-nitro-l-arginine.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599905
06AnimalAnimal study (in vivo)Efficacy outcome
In wild-type mice with NOS inhibition, late AICAR preconditioning did not prevent postischemic leukocyte rolling.
In plain wordsIn mice with NOS inhibition, late AICAR treatment did not prevent leukocyte rolling compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
No significant changeLate preconditioning leukocyte rolling with NOS inhibition
Study
mousen: not reported in source
Wild-type mice treated with NOS inhibitor
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 24 h before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC was ineffective in preventing I/R-induced LR but not LA in the eNOS(-/-) mice, and the same pattern was seen in WT animals treated with the NOS inhibitor N(omega)-nitro-l-arginine.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599906
07AnimalAnimal study (in vivo)Efficacy outcome
In wild-type mice with NOS inhibition, late AICAR preconditioning prevented postischemic leukocyte adhesion.
In plain wordsIn mice with NOS inhibition, late AICAR treatment reduced leukocyte adhesion compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
DecreaseLate preconditioning leukocyte adhesion with NOS inhibition
Study
mousen: not reported in source
Wild-type mice treated with NOS inhibitor
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 24 h before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Late AICAR PC was ineffective in preventing I/R-induced LR but not LA in the eNOS(-/-) mice, and the same pattern was seen in WT animals treated with the NOS inhibitor N(omega)-nitro-l-arginine.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599907
08AnimalAnimal study (in vivo)Efficacy outcome
In eNOS-deficient mice, early AICAR preconditioning prevented postischemic leukocyte adhesion.
In plain wordsIn mice without eNOS, early AICAR treatment reduced leukocyte adhesion compared with ischemia without AICAR.
Peptide
AICAR (acadesine)
Outcome
DecreaseEarly preconditioning leukocyte adhesion in eNOS knockout
Study
mousen: not reported in source
eNOS knockout mice with jejunal ischemia-reperfusion
Comparator
Ischemia-reperfusion without AICAR
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · 30 min before ischemia-reperfusionAs given in this study (mouse).
Source sentences
Summary
Early AICAR PC remained effective in preventing LA in eNOS(-/-) mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Wild-type (WT) C57BL/6J and eNOS(-/-) mice were treated with the AMPK agonist 5-aminoimidazole-4-carboxamide 1-beta-d-furanoside (AICAR) 30 min (early AICAR PC) or 24 h (late AICAR PC) before I/R; LR and LA were quantified in single postcapillary venules in the jejunum using intravital microscopy.
Report a problemFND-1693599908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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