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Study · Animal study (in vivo) · mouse · 2007

16 results

Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma.

Kim TB, Kim SY, Moon KA, Park CS, Jang MK, Yun ES, Cho YS, Moon HB, Lee KY

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology17 Sept 2007Cited by 27 (Europe PMC)

PMID17877757 (opens in a new tab)DOI10.1111/j.1365-2222.2007.02812.x (opens in a new tab)PepBankPUB-17877757
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with OVA-induced asthma, AICAR had a marginal inhibitory effect.

    In plain wordsIn mice with OVA-induced asthma, AICAR had a small inhibitory effect compared with the model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseInhibitory effect in OVA-induced asthma
    Study

    mousen: not reported in source

    OVA-induced asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR was shown to have a marginal inhibitory effect in an OVA-induced asthma model.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with OVA plus poly(I:C)-induced asthma, AICAR significantly attenuated airway hyperresponsiveness.

    In plain wordsIn mice, AICAR reduced airway overreaction compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAirway hyperresponsiveness
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with OVA plus poly(I:C)-induced asthma, AICAR significantly attenuated airway inflammation.

    In plain wordsIn mice, AICAR reduced airway inflammation compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAirway inflammation
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced total inflammatory cell influx into bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced inflammatory cells in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTotal inflammatory cell influx
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced macrophage influx into bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced macrophages in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseMacrophage influx
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced eosinophil influx into bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced eosinophils in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseEosinophil influx
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced IL-5 in bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced IL-5 in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLavage IL-5
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced IL-13 in bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced IL-13 in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLavage IL-13
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced TNF-alpha in bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced TNF-alpha in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLavage TNF-alpha
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR reduced IFN-gamma in bronchoalveolar lavage fluid.

    In plain wordsIn mice, AICAR reduced IFN-gamma in lung wash fluid compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLavage IFN-gamma
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, AICAR significantly attenuated poly (I:C)-induced airway hyperresponsiveness and airway inflammation, as shown by the attenuation of the influx of total inflammatory cells and soluble products into bronchoalveolar lavage fluid, such as macrophages, eosinophils, IL-5, IL-13, TNF-alpha and IFN-gamma.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR significantly reduced serum OVA-specific IgE.

    In plain wordsIn mice, AICAR reduced OVA-specific IgE compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOVA-specific serum IgE
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR also significantly reduced the serum levels of OVA-specific IgE and IgG2a antibodies.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR significantly reduced serum OVA-specific IgG2a.

    In plain wordsIn mice, AICAR reduced OVA-specific IgG2a compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseOVA-specific serum IgG2a
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR also significantly reduced the serum levels of OVA-specific IgE and IgG2a antibodies.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, histologic and flow cytometric studies showed that AICAR inhibited poly(I:C)-induced lung inflammation.

    In plain wordsIn mice, AICAR reduced lung inflammation compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHistologic lung inflammation
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histologic and flow cytometric studies showed that AICAR inhibited poly (I:C)-induced lung inflammation and the infiltration of CD11b+CD11c+ dendritic cells into the lung.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In asthmatic mice, AICAR inhibited lung infiltration by CD11b+CD11c+ dendritic cells.

    In plain wordsIn mice, AICAR reduced dendritic cell entry into lungs compared with the asthma model without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLung dendritic cell infiltration
    Study

    mousen: not reported in source

    OVA plus poly(I:C) asthma model
    Comparator
    Asthma model without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histologic and flow cytometric studies showed that AICAR inhibited poly (I:C)-induced lung inflammation and the infiltration of CD11b+CD11c+ dendritic cells into the lung.
    1 context sentence
    Summary · context
    The anti-inflammatory effects of AICAR were evaluated in two experimental asthma models: (1) an ovalbumin (OVA)-induced experimental asthma model and (2) an OVA plus polyinosinic-polycytidylic acid [poly (I:C)]-induced experimental asthma model to mimic respiratory viral infections.
  15. 15LabIn vitro (cells)Mechanism

    In vitro, AICAR inhibited poly(I:C)-mediated NF-kappaB activation.

    In plain wordsIn lab tests, AICAR reduced NF-kappaB activation compared with poly(I:C) without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNF-kappaB activation
    Study

    n: not reported in source

    In vitro poly(I:C)-mediated signaling
    Comparator
    Poly(I:C) without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, AICAR effectively inhibited poly (I:C)-mediated activation of NF-kappaB and the production of TNF-alpha.
    1 context sentence
    Summary · context
    The inhibitory effects of AICAR in poly (I:C)-mediated signalling for NF-kappaB activation and production of TNF-alpha were analysed in vitro.
  16. 16LabIn vitro (cells)Mechanism

    In vitro, AICAR inhibited poly(I:C)-mediated TNF-alpha production.

    In plain wordsIn lab tests, AICAR reduced TNF-alpha production compared with poly(I:C) without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseTNF-alpha production in vitro
    Study

    n: not reported in source

    In vitro poly(I:C)-mediated signaling
    Comparator
    Poly(I:C) without AICAR
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, AICAR effectively inhibited poly (I:C)-mediated activation of NF-kappaB and the production of TNF-alpha.
    1 context sentence
    Summary · context
    The inhibitory effects of AICAR in poly (I:C)-mediated signalling for NF-kappaB activation and production of TNF-alpha were analysed in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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