In rats, AMPK alpha2 activity responded equally to AICAR in old and young adult muscles.
In plain wordsIn rats, old and young adult muscles showed equal AMPK alpha2 activity responses to AICAR.
- Peptide
- AICAR (acadesine)
- Outcome
- No significant changeAMPK alpha2 activity response
- Study
ratn: not reported in source
Fischer(344) x Brown Norway skeletal muscle- Comparator
- young adult rats
- Outcome group
- Receptor activity and mechanism · Musculoskeletal
- Studied dose
- 1 mg (g body weight)(-1) · subcutaneous · 1 hAs given in this study (rat).
Source sentences
In contrast, AMPK alpha2 activity was equally responsive to AICAR treatment in both age groups.
2 context sentences(design, population, supporting numbers)
Here we tested the hypothesis that AMPK would also be hyperactivated in O vs YA fast-twitch extensor digitorum longus muscles from Fischer(344) x Brown Norway (FBN) rats (n = 8 per group) in response to high-frequency electrical stimulation of the sciatic nerve (HFES) or injection of AICAR, an activator of AMPK.
Muscles were harvested immediately after HFES (10 sets of six 3-s contractions, 10 s rest between contractions, 1 min rest between sets) or 1 h after AICAR injection (1 mg (g body weight)(-1) subcutaneously).