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Study · Animal study (in vivo) · mouse · 2009

3 results

AICAR preconditioning prevents postischemic leukocyte rolling and adhesion: role of K(ATP) channels and heme oxygenase.

Gaskin FS, Kamada K, Yusof M, Durante W, Gross G, Korthuis RJ

Microcirculation (New York, N.Y. : 1994)1 Feb 2009Cited by 27 (Europe PMC)

PMID19152177 (opens in a new tab)PMCIDPMC2784925 (opens in a new tab)DOI10.1080/10739680802355897 (opens in a new tab)PepBankPUB-19152177
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, AICAR preconditioning prevented the ischemia/reperfusion-induced increase in leukocyte-endothelial adhesive interactions.

    In plain wordsIn mice, AICAR preconditioning prevented increased leukocyte adhesion after ischemia/reperfusion compared with no preconditioning.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseLeukocyte-endothelial adhesive interactions
    Study

    mousen: not reported in source

    intestinal ischemia/reperfusion in C57BL/6J mice
    Comparator
    ischemia/reperfusion without AICAR preconditioning
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · 24 hours prior to I/RAs given in this study (mouse).

    Source sentences

    Summary
    I/R induced marked increases in LEI relative to sham control mice, proadhesive responses that were prevented by AICAR-PC 24 hours prior to I/R.
    1 context sentence
    Summary · context
    Intravital fluorescence microscopy was used to quantify LEI in the small intestine of AICAR-preconditioned C57BL/6J mice treated with K(ATP) channel or heme oxygenase inhibitors during I/R 24 hours after AICAR-PC in separate experiments.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 02AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mice, K(ATP) channel inhibition abolished the antiadhesive effect of AICAR preconditioning during ischemia/reperfusion.

    In plain wordsIn mice, potassium channel inhibition removed AICAR preconditioning's protection against leukocyte adhesion compared with preconditioning alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseK(ATP)-dependent antiadhesive response
    Study

    mousen: not reported in source

    intestinal ischemia/reperfusion in C57BL/6J mice
    Comparator
    AICAR preconditioning without K(ATP) inhibition
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The effects of AICAR-PC to prevent postischemic LEI were abolished by K(ATP) channel or heme oxygenase inhibition during I/R.
    1 context sentence
    Summary · context
    Intravital fluorescence microscopy was used to quantify LEI in the small intestine of AICAR-preconditioned C57BL/6J mice treated with K(ATP) channel or heme oxygenase inhibitors during I/R 24 hours after AICAR-PC in separate experiments.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 03AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Mechanism

    In mice, heme oxygenase inhibition abolished the antiadhesive effect of AICAR preconditioning during ischemia/reperfusion.

    In plain wordsIn mice, heme oxygenase inhibition removed AICAR preconditioning's protection against leukocyte adhesion compared with preconditioning alone.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHeme oxygenase-dependent antiadhesive response
    Study

    mousen: not reported in source

    intestinal ischemia/reperfusion in C57BL/6J mice
    Comparator
    AICAR preconditioning without heme oxygenase inhibition
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    The effects of AICAR-PC to prevent postischemic LEI were abolished by K(ATP) channel or heme oxygenase inhibition during I/R.
    1 context sentence
    Summary · context
    Intravital fluorescence microscopy was used to quantify LEI in the small intestine of AICAR-preconditioned C57BL/6J mice treated with K(ATP) channel or heme oxygenase inhibitors during I/R 24 hours after AICAR-PC in separate experiments.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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