In rats with sciatic nerve constriction injury, AMPK agonist treatment inhibited phosphorylation of related MAPK pathway proteins.
In plain wordsIn rats with nerve constriction injury, AMPK agonist treatment reduced pathway protein phosphorylation compared with the injury model group.
- Peptide
- AICAR (acadesine)
- Outcome
- DecreaseMAPK-related protein phosphorylation
- Study
ratn: not reported in source
sciatic nerve chronic constriction injury- Comparator
- CCI model group
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated · 28 daysAs given in this study (rat).
Source sentences
After treatment with que and AMPK agonists, the phosphorylation levels of related proteins were inhibited.
4 context sentences(design, population, supporting numbers)
Western blotting results showed that p-38 MAPK, p-ERK, and p-JNK were activated in the spinal dorsal horn of CCI model group.
CCI model was established by ligating the sciatic nerve of right leg on the SD rats.
They were divided into ten groups: sham group, CCI model, sham+ que, CCI+ que group (30, 60, 120 mg/kg), CCI+ AICAR, CCI+ que+ compound C, CCI+etoricoxib, and the control group.
They were administered for 28 days, and were performed the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) during the experiment.