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Study · Animal study (in vivo) · mouse · 2017

5 results

AMPK attenuates ventricular remodeling and dysfunction following aortic banding in mice via the Sirt3/Oxidative stress pathway.

Chen Y, Chen C, Dong B, Xing F, Huang H, Yao F, Ma Y, He J, Dong Y

European journal of pharmacology1 Sept 2017Cited by 21 (Europe PMC)

PMID28867609 (opens in a new tab)DOI10.1016/j.ejphar.2017.08.042 (opens in a new tab)PepBankPUB-28867609
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aortic-banded mice, AICAR-mediated AMPK activation attenuated cardiac remodeling parameters.

    In plain wordsIn mice, AMPK activation with AICAR reduced cardiac remodeling compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCardiac remodeling parameters
    Study

    mousen: not reported in source

    aortic-banded mice
    Comparator
    vehicle-treated aortic-banded mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.5 mg/g/day · subcutaneous · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    AMPK attenuate the cardiac remodeling parameters and improve cardiac function.
    1 context sentence
    Summary · context
    Mice with descending aortic banding (AB) or subjected to sham operation received subcutaneous injection of either AICAR (0.5mgg-1day-1) or vehicle over 4 week periods.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aortic-banded mice, AICAR-mediated AMPK activation improved cardiac function.

    In plain wordsIn mice, AMPK activation with AICAR improved heart function compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCardiac function
    Study

    mousen: not reported in source

    aortic-banded mice
    Comparator
    vehicle-treated aortic-banded mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.5 mg/g/day · subcutaneous · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    AMPK attenuate the cardiac remodeling parameters and improve cardiac function.
    1 context sentence
    Summary · context
    Mice with descending aortic banding (AB) or subjected to sham operation received subcutaneous injection of either AICAR (0.5mgg-1day-1) or vehicle over 4 week periods.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In aortic-banded mice, AICAR-mediated AMPK activation inhibited NOX2 expression.

    In plain wordsIn mice, AMPK activation with AICAR reduced NOX2 expression compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNOX2 expression
    Study

    mousen: not reported in source

    aortic-banded mice
    Comparator
    vehicle-treated aortic-banded mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    0.5 mg/g/day · subcutaneous · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    AMPK was able to significantly inhibit NOX2, NOX4 expression, while activate Sirt3 expression.
    1 context sentence
    Summary · context
    Mice with descending aortic banding (AB) or subjected to sham operation received subcutaneous injection of either AICAR (0.5mgg-1day-1) or vehicle over 4 week periods.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In aortic-banded mice, AICAR-mediated AMPK activation inhibited NOX4 expression.

    In plain wordsIn mice, AMPK activation with AICAR reduced NOX4 expression compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseNOX4 expression
    Study

    mousen: not reported in source

    aortic-banded mice
    Comparator
    vehicle-treated aortic-banded mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    0.5 mg/g/day · subcutaneous · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    AMPK was able to significantly inhibit NOX2, NOX4 expression, while activate Sirt3 expression.
    1 context sentence
    Summary · context
    Mice with descending aortic banding (AB) or subjected to sham operation received subcutaneous injection of either AICAR (0.5mgg-1day-1) or vehicle over 4 week periods.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In aortic-banded mice, AICAR-mediated AMPK activation activated Sirt3 expression.

    In plain wordsIn mice, AMPK activation with AICAR increased Sirt3 expression compared with vehicle.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseSirt3 expression
    Study

    mousen: not reported in source

    aortic-banded mice
    Comparator
    vehicle-treated aortic-banded mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    0.5 mg/g/day · subcutaneous · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    AMPK was able to significantly inhibit NOX2, NOX4 expression, while activate Sirt3 expression.
    1 context sentence
    Summary · context
    Mice with descending aortic banding (AB) or subjected to sham operation received subcutaneous injection of either AICAR (0.5mgg-1day-1) or vehicle over 4 week periods.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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