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Study · Animal study (in vivo) · caenorhabditis elegans · 2017

1 result

Metformin Attenuates Aβ Pathology Mediated Through Levamisole Sensitive Nicotinic Acetylcholine Receptors in a C. elegans Model of Alzheimer's Disease.

Ahmad W, Ebert PR

Molecular neurobiology5 Sept 2016Cited by 42 (Europe PMC)

PMID27596506 (opens in a new tab)DOI10.1007/s12035-016-0085-y (opens in a new tab)PepBankPUB-27596506
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In amyloid-beta-expressing C. elegans, AICAR showed a protective effect against amyloid-beta toxicity similar to metformin.

    In plain wordsIn worms expressing human amyloid-beta, AICAR protected against its toxicity, with an effect similar to metformin.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseAmyloid-beta toxicity
    Study

    Caenorhabditis elegansn: not reported in source

    Human amyloid-beta expressing worms
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AICAR has a similar protective effect against Aβ toxicity.
    1 context sentence
    Summary · context
    In this study, we have investigated the effects of metformin and another T2DM drug, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) in C. elegans expressing human Aβ42.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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