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Study · Animal study (in vivo) · mouse · 2026

12 results

Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury.

Song Z, Ban Z, Zhao H, Mei X

Neurochemistry international2 May 2026Cited by 1 (Europe PMC)

PMID42082001 (opens in a new tab)DOI10.1016/j.neuint.2026.106171 (opens in a new tab)PepBankPUB-42082001
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with thoracic contusion spinal cord injury, SS‑31 significantly enhanced locomotor recovery.

    In plain wordsIn mice with spinal cord injury, SS‑31 improved recovery of movement.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseLocomotor recovery
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with thoracic contusion spinal cord injury, SS‑31 significantly enhanced gait performance.

    In plain wordsIn mice with spinal cord injury, SS‑31 improved walking pattern.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGait performance
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, histology showed reduced lesion pathology with SS‑31.

    In plain wordsIn mice with spinal cord injury, SS‑31 was linked to smaller tissue damage in the injured spinal cord.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSpinal cord lesion pathology
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histological analyses showed reduced lesion pathology and increased neuronal preservation in the injured spinal cord.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, histology showed increased neuronal preservation with SS‑31.

    In plain wordsIn mice with spinal cord injury, SS‑31 was linked to more nerve cells surviving in the injured spinal cord.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseNeuronal preservation
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Histological analyses showed reduced lesion pathology and increased neuronal preservation in the injured spinal cord.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 reduced cleaved caspase-3 early after injury.

    In plain wordsIn mice with spinal cord injury, SS‑31 lowered a marker of cell death early after injury.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCleaved caspase-3
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Early after injury, SS-31 attenuated apoptosis signaling, evidenced by reduced cleaved caspase-3 and Bax and increased Bcl-2.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 reduced Bax early after injury.

    In plain wordsIn mice with spinal cord injury, SS‑31 lowered a cell-death protein (Bax) early after injury.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBax
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Early after injury, SS-31 attenuated apoptosis signaling, evidenced by reduced cleaved caspase-3 and Bax and increased Bcl-2.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, SS‑31 increased Bcl-2 early after injury.

    In plain wordsIn mice with spinal cord injury, SS‑31 raised a cell-survival protein (Bcl-2) early after injury.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseBcl-2
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Early after injury, SS-31 attenuated apoptosis signaling, evidenced by reduced cleaved caspase-3 and Bax and increased Bcl-2.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, SS‑31 was associated with diminished astrogliosis at the chronic stage.

    In plain wordsIn mice with spinal cord injury, SS‑31 was linked to less scar-forming glial activation at the chronic stage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAstrogliosis at the chronic stage
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the chronic stage, SS-31 was associated with diminished astrogliosis and enhanced markers of axonal and synaptic remodeling.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with spinal cord injury, SS‑31 was associated with enhanced markers of axonal and synaptic remodeling at the chronic stage.

    In plain wordsIn mice with spinal cord injury, SS‑31 was linked to higher markers of nerve fibre and synapse remodeling at the chronic stage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseAxonal and synaptic remodeling markers
    Study

    mousen: not reported in source

    Mouse thoracic contusion spinal cord injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the chronic stage, SS-31 was associated with diminished astrogliosis and enhanced markers of axonal and synaptic remodeling.
    1 context sentence
    Summary · context
    In a mouse thoracic contusion model, SS-31 treatment significantly enhanced locomotor recovery and gait performance.
  10. 10LabIn vitro (cells)Mechanism

    In oxidatively stressed PC12 cells, SS‑31 preserved mitochondrial membrane potential.

    In plain wordsIn cells under oxidative stress, SS‑31 helped keep mitochondrial membrane potential.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    n: not reported in source

    Oxidatively stressed PC12 cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In oxidatively stressed PC12 cells, SS-31 preserved mitochondrial membrane potential, reduced ROS accumulation, and supported oxidative phosphorylation-related protein integrity.
  11. 11LabIn vitro (cells)Mechanism

    In oxidatively stressed PC12 cells, SS‑31 reduced ROS accumulation.

    In plain wordsIn cells under oxidative stress, SS‑31 reduced build-up of reactive oxygen molecules.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseROS accumulation
    Study

    n: not reported in source

    Oxidatively stressed PC12 cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In oxidatively stressed PC12 cells, SS-31 preserved mitochondrial membrane potential, reduced ROS accumulation, and supported oxidative phosphorylation-related protein integrity.
  12. 12LabIn vitro (cells)Mechanism

    In oxidatively stressed PC12 cells, SS‑31 supported the integrity of oxidative phosphorylation-related proteins.

    In plain wordsIn cells under oxidative stress, SS‑31 helped protect proteins that make cell energy.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseOxidative phosphorylation-related protein integrity
    Study

    n: not reported in source

    Oxidatively stressed PC12 cells
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In oxidatively stressed PC12 cells, SS-31 preserved mitochondrial membrane potential, reduced ROS accumulation, and supported oxidative phosphorylation-related protein integrity.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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