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Study · Animal study (in vivo) · mouse · 2020

3 results

Arsenic Directs Stem Cell Fate by Imparting Notch Signaling Into the Extracellular Matrix Niche.

Anguiano T, Sahu A, Qian B, Tang WY, Ambrosio F, Barchowsky A

Toxicological sciences : an official journal of the Society of Toxicology1 Oct 2020Cited by 8 (Europe PMC)

PMID32647881 (opens in a new tab)PMCIDPMC7548290 (opens in a new tab)DOI10.1093/toxsci/kfaa106 (opens in a new tab)PepBankPUB-32647881
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In arsenic-exposed mice, SS‑31 reversed the arsenic-promoted fibroblast phenotype to one that made an ECM supporting normal myogenic differentiation.

    In plain wordsIn mice exposed to arsenic, SS‑31 restored muscle-supporting tissue so that muscle stem cells could develop normally.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseConnective tissue fibroblast ECM supporting myogenic differentiation
    Study

    mousen: not reported in source

    mice exposed to arsenic in drinking water
    Comparator
    Arsenic-exposed mice without SS-31
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, treating arsenic-exposed mice with SS-31, a mitochondrially targeted peptide that repairs the respiratory chain, reversed the arsenic-promoted CTF phenotype to one that elaborated an ECM supporting normal myogenic differentiation.
    1 context sentence
    Summary · context
    To investigate the signaling mechanisms involved in imparting a dysfunctional ECM, we isolated skeletal muscle tissue and CTF from mice exposed to 0 or 100 μg/l arsenic in their drinking water for 5 weeks.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In arsenic-exposed mice, SS‑31 treatment reversed arsenic-induced Notch1 expression.

    In plain wordsIn mice exposed to arsenic, SS‑31 reversed the rise in Notch1, a signaling protein.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseArsenic-induced Notch1 expression
    Study

    mousen: not reported in source

    mice exposed to arsenic in drinking water
    Comparator
    Arsenic-exposed mice without SS-31
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 treatment also reversed arsenic-induced Notch1 expression
    1 context sentence
    Summary · context
    To investigate the signaling mechanisms involved in imparting a dysfunctional ECM, we isolated skeletal muscle tissue and CTF from mice exposed to 0 or 100 μg/l arsenic in their drinking water for 5 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In arsenic-exposed mice, SS‑31 treatment improved muscle regeneration after injury.

    In plain wordsIn mice exposed to arsenic, SS‑31 improved muscle regrowth after injury.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMuscle regeneration after injury
    Study

    mousen: not reported in source

    mice exposed to arsenic in drinking water
    Comparator
    Arsenic-exposed mice without SS-31
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 treatment also reversed arsenic-induced Notch1 expression, resulting in an improved muscle regeneration after injury.
    1 context sentence
    Summary · context
    To investigate the signaling mechanisms involved in imparting a dysfunctional ECM, we isolated skeletal muscle tissue and CTF from mice exposed to 0 or 100 μg/l arsenic in their drinking water for 5 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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