Skip to content

Study · Animal study (in vivo) · rat · 2021

6 results

SS-31 ameliorates hepatic injury in rats subjected to severe burns plus delayed resuscitation via inhibiting the mtDNA/STING pathway in Kupffer cells.

Wu Y, Hao C, Han G, Liu X, Xu C, Zou Z, Zhou J, Yin J

Biochemical and biophysical research communications11 Feb 2021Cited by 9 (Europe PMC)

PMID33582556 (opens in a new tab)DOI10.1016/j.bbrc.2021.01.110 (opens in a new tab)PepBankPUB-33582556
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe burns plus delayed resuscitation, SS‑31 prevented hepatic injury.

    In plain wordsIn rats with severe burns, SS‑31 prevented liver injury.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHepatic injury
    Study

    ratn: not reported in source

    Severe burns plus delayed resuscitation (B + DR)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented hepatic injury by neutralizing ROS, inhibiting the release of mtDNA, protecting hepatocyte mitochondria, suppressing the activation of the mtDNA/STING pathway and inhibiting KCs polarization into pro-inflammatory phenotype.
    1 context sentence
    Summary · context
    Hepatic injury is common in patients who suffer from severe burns plus delayed resuscitation (B + DR).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with severe burns plus delayed resuscitation, SS‑31 neutralized reactive oxygen species.

    In plain wordsIn rats with severe burns, SS‑31 neutralized harmful reactive oxygen molecules in the liver.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseReactive oxygen species
    Study

    ratn: not reported in source

    Severe burns plus delayed resuscitation (B + DR)
    Outcome group
    Oxidative stress · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented hepatic injury by neutralizing ROS, inhibiting the release of mtDNA, protecting hepatocyte mitochondria, suppressing the activation of the mtDNA/STING pathway and inhibiting KCs polarization into pro-inflammatory phenotype.
    1 context sentence
    Summary · context
    Hepatic injury is common in patients who suffer from severe burns plus delayed resuscitation (B + DR).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with severe burns plus delayed resuscitation, SS‑31 inhibited the release of mitochondrial DNA.

    In plain wordsIn rats with severe burns, SS‑31 reduced the release of mitochondrial DNA.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRelease of mtDNA
    Study

    ratn: not reported in source

    Severe burns plus delayed resuscitation (B + DR)
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented hepatic injury by neutralizing ROS, inhibiting the release of mtDNA, protecting hepatocyte mitochondria, suppressing the activation of the mtDNA/STING pathway and inhibiting KCs polarization into pro-inflammatory phenotype.
    1 context sentence
    Summary · context
    Hepatic injury is common in patients who suffer from severe burns plus delayed resuscitation (B + DR).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with severe burns plus delayed resuscitation, SS‑31 protected hepatocyte mitochondria.

    In plain wordsIn rats with severe burns, SS‑31 protected the energy-producing parts of liver cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableHepatocyte mitochondria protection
    Study

    ratn: not reported in source

    Severe burns plus delayed resuscitation (B + DR)
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented hepatic injury by neutralizing ROS, inhibiting the release of mtDNA, protecting hepatocyte mitochondria, suppressing the activation of the mtDNA/STING pathway and inhibiting KCs polarization into pro-inflammatory phenotype.
    1 context sentence
    Summary · context
    Hepatic injury is common in patients who suffer from severe burns plus delayed resuscitation (B + DR).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with severe burns plus delayed resuscitation, SS‑31 suppressed activation of the mtDNA/STING pathway.

    In plain wordsIn rats with severe burns, SS‑31 reduced activation of the mtDNA/STING inflammation pathway.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasemtDNA/STING pathway activation
    Study

    ratn: not reported in source

    Severe burns plus delayed resuscitation (B + DR)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented hepatic injury by neutralizing ROS, inhibiting the release of mtDNA, protecting hepatocyte mitochondria, suppressing the activation of the mtDNA/STING pathway and inhibiting KCs polarization into pro-inflammatory phenotype.
    1 context sentence
    Summary · context
    Hepatic injury is common in patients who suffer from severe burns plus delayed resuscitation (B + DR).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with severe burns plus delayed resuscitation, SS‑31 inhibited polarization of Kupffer cells into a pro-inflammatory phenotype.

    In plain wordsIn rats with severe burns, SS‑31 reduced the shift of liver immune cells to an inflammatory state.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseKupffer cell pro-inflammatory polarization
    Study

    ratn: not reported in source

    Severe burns plus delayed resuscitation (B + DR)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 prevented hepatic injury by neutralizing ROS, inhibiting the release of mtDNA, protecting hepatocyte mitochondria, suppressing the activation of the mtDNA/STING pathway and inhibiting KCs polarization into pro-inflammatory phenotype.
    1 context sentence
    Summary · context
    Hepatic injury is common in patients who suffer from severe burns plus delayed resuscitation (B + DR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.