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Study · Animal study (in vivo) · mouse · 2024

3 results

Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene.

Gao L, Zuo XL, Dong LL, Zhou SF, Wang ZJ, Duan YS, Chen MY, Zhu QX, Zhang JX

Ecotoxicology and environmental safety13 Apr 2024Cited by 12 (Europe PMC)

PMID38615641 (opens in a new tab)DOI10.1016/j.ecoenv.2024.116317 (opens in a new tab)PepBankPUB-38615641
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with trichloroethylene-induced immune liver injury, SS‑31 pretreatment reduced oxidative stress in hepatocytes.

    In plain wordsIn mice with chemical-induced liver injury, SS‑31 given beforehand lowered oxidative stress in liver cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHepatocyte oxidative stress
    Study

    mousen: not reported in source

    Trichloroethylene (TCE)-induced immune liver injury
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pretreatment with SS-31, a mitochondria-targeting antioxidant peptide, reduced the level of oxidative stress in hepatocytes
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with trichloroethylene-induced immune liver injury, SS‑31 pretreatment decreased the release of mitochondrial DNA from hepatocytes.

    In plain wordsIn mice with chemical-induced liver injury, SS‑31 given beforehand reduced release of mitochondrial DNA from liver cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHepatocyte mtDNA release
    Study

    mousen: not reported in source

    Trichloroethylene (TCE)-induced immune liver injury
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    pretreatment with SS-31, a mitochondria-targeting antioxidant peptide, reduced the level of oxidative stress in hepatocytes, leading to a decrease in mtDNA release
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with trichloroethylene-induced immune liver injury, SS‑31 pretreatment inhibited TLR9 activation in macrophages.

    In plain wordsIn mice with chemical-induced liver injury, SS‑31 given beforehand reduced activation of the immune sensor TLR9 in macrophages.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTLR9 activation in macrophages
    Study

    mousen: not reported in source

    Trichloroethylene (TCE)-induced immune liver injury
    Outcome group
    Inflammation markers · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Importantly, SS-31 pretreatment inhibited TLR9 activation in macrophages, suggesting that hepatocyte mtDNA may activate TLR9 in macrophages.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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