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Study · Animal study (in vivo) · mouse · 2021

7 results

[Protective effect of mitochondria-targeted antioxidant peptide SS-31 in sepsis-induced acute kidney injury].

Sun M, Ma J, Ye J, Fan H, Le J, Zhu J

Zhonghua wei zhong bing ji jiu yi xue1 Dec 2021Cited by 8 (Europe PMC)

PMID35131006 (opens in a new tab)DOI10.3760/cma.j.cn121430-20210719-01063 (opens in a new tab)PepBankPUB-35131006
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with sepsis-induced acute kidney injury, SS‑31 lowered serum creatinine compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 lowered serum creatinine compared with untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSerum creatinine
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    SCr
    71.33 μmol/L
    SS-31 group
    SCr
    93.12 μmol/L
    sepsis model group

    Source sentences

    Summary
    compared with sepsis model group, the levels of SCr, BUN and the expressions of AMPK, PGC-1α, cleaved caspase-3 protein were significantly decreased in the SS-31 peptide group
    3 context sentences
    Summary · context
    [SCr (μmol/L): 71.33±10.14 vs. 93.12±11.80, BUN (mmol/L): 27.00±5.52 vs. 41.36±6.48, AMPK/β-actin: 0.23±0.01 vs. 0.30±0.02, PGC-1α/β-actin: 0.27±0.02 vs. 0.38±0.03, cleaved caspase-3/β-actin: 0.13±0.01 vs. 0.20±0.01, all P < 0.05].
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with sepsis-induced acute kidney injury, SS‑31 lowered blood urea nitrogen compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 lowered blood urea nitrogen compared with untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBlood urea nitrogen
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Measurements

    BUN
    27 mmol/L
    SS-31 group
    BUN
    41.36 mmol/L
    sepsis model group

    Source sentences

    Summary
    compared with sepsis model group, the levels of SCr, BUN and the expressions of AMPK, PGC-1α, cleaved caspase-3 protein were significantly decreased in the SS-31 peptide group
    3 context sentences
    Summary · context
    BUN (mmol/L): 27.00±5.52 vs. 41.36±6.48, AMPK/β-actin: 0.23±0.01 vs. 0.30±0.02, PGC-1α/β-actin: 0.27±0.02 vs. 0.38±0.03, cleaved caspase-3/β-actin: 0.13±0.01 vs. 0.20±0.01, all P < 0.05].
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis-induced acute kidney injury, SS‑31 lowered kidney AMPK protein expression compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 lowered kidney AMPK protein compared with untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseKidney AMPK protein expression
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    compared with sepsis model group, the levels of SCr, BUN and the expressions of AMPK, PGC-1α, cleaved caspase-3 protein were significantly decreased in the SS-31 peptide group
    3 context sentences
    Summary · context
    AMPK/β-actin: 0.23±0.01 vs. 0.30±0.02, PGC-1α/β-actin: 0.27±0.02 vs. 0.38±0.03, cleaved caspase-3/β-actin: 0.13±0.01 vs. 0.20±0.01, all P < 0.05].
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis-induced acute kidney injury, SS‑31 lowered kidney PGC-1α protein expression compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 lowered kidney PGC-1α protein compared with untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseKidney PGC-1α protein expression
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    compared with sepsis model group, the levels of SCr, BUN and the expressions of AMPK, PGC-1α, cleaved caspase-3 protein were significantly decreased in the SS-31 peptide group
    3 context sentences
    Summary · context
    PGC-1α/β-actin: 0.27±0.02 vs. 0.38±0.03, cleaved caspase-3/β-actin: 0.13±0.01 vs. 0.20±0.01, all P < 0.05].
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis-induced acute kidney injury, SS‑31 lowered kidney cleaved caspase-3 protein compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 lowered a kidney cell-death protein compared with untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseKidney cleaved caspase-3 protein expression
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    compared with sepsis model group, the levels of SCr, BUN and the expressions of AMPK, PGC-1α, cleaved caspase-3 protein were significantly decreased in the SS-31 peptide group
    3 context sentences
    Summary · context
    cleaved caspase-3/β-actin: 0.13±0.01 vs. 0.20±0.01, all P < 0.05].
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis-induced acute kidney injury, SS‑31 reduced the number of apoptotic kidney cells compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 reduced the number of dying kidney cells compared with untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseApoptotic cells in kidney (TUNEL)
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    the number of apoptotic cells was significantly reduced [cells: 13.00 (9.00, 16.50) vs. 24.00 (18.75, 31.00), P < 0.05].
    2 context sentences
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with sepsis-induced acute kidney injury, SS‑31 reduced cell swelling and kept mitochondrial and membrane structure relatively intact compared with the sepsis model group.

    In plain wordsIn mice with sepsis kidney injury, SS‑31 kept kidney mitochondria more intact than in untreated sepsis mice.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseKidney mitochondrial and tissue damage on microscopy
    Study

    mousen: not reported in source

    Cecal ligation and puncture sepsis-induced acute kidney injury
    Comparator
    Sepsis model group (saline)
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    5 mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    HE staining showed that cell swelling reduced, the mitochondrial structure was intact, the ridge swelling was also reduced, and the membrane structure was relatively intact
    2 context sentences
    Summary · context
    The sepsis-induced AKI mouse model was reproduced by cecal ligation and puncture (CLP).
    Summary · context
    SS-31 peptide (5 mg/kg) was intraperitoneally injected in SS-31 peptide group and positive control group 30 minutes after the operation, while an equivalent amount of normal saline was given in sham group and sepsis model group for 7 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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