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Study · Animal study (in vivo) · mouse · 2022

1 result

Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice.

Campbell MD, Martín-Pérez M, Egertson JD, Gaffrey MJ, Wang L, Bammler T, Rabinovitch PS, MacCoss M, Qian WJ, Villen J, Marcinek D

GeroScience2 Nov 2022Cited by 9 (Europe PMC)

PMID36322234 (opens in a new tab)PMCIDPMC9768078 (opens in a new tab)DOI10.1007/s11357-022-00679-0 (opens in a new tab)PepBankPUB-36322234
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Summary

The age-related decline in skeletal muscle mass and function is known as sarcopenia. Sarcopenia progresses based on complex processes involving protein dynamics, cell signaling, oxidative stress, and repair. We have previously found that 8-week treatment with elamipretide improves skeletal muscle function, reverses redox stress, and restores protein S-glutathionylation changes in aged female mice. This study tested whether 8-week treatment with elamipretide also affects global phosphorylation in skeletal muscle consistent with functional improvements and S-glutathionylation. Using female 6-7-month-old mice and 28-29-month-old mice, we found that phosphorylation changes did not relate to S-glutathionylation modifications, but that treatment with elamipretide did partially reverse age-related changes in protein phosphorylation in mouse skeletal muscle.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In aged female mice, 8-week elamipretide treatment partially reversed age-related changes in skeletal muscle protein phosphorylation.

    In plain wordsIn old female mice, eight weeks of elamipretide partly reversed age-related changes in muscle protein phosphorylation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    MixedAge-related changes in skeletal muscle protein phosphorylation
    Study

    mousen: not reported in source

    aged female mice, skeletal muscle
    Comparator
    Young mice
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated · 8 weeksAs given in this study (mouse).

    Source sentences

    Summary
    treatment with elamipretide did partially reverse age-related changes in protein phosphorylation in mouse skeletal muscle
    1 context sentence
    Summary · context
    This study tested whether 8-week treatment with elamipretide also affects global phosphorylation in skeletal muscle consistent with functional improvements and S-glutathionylation.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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