In horses with impact injury to articular cartilage, intraarticular SS‑31 mitigated impact-induced mtDNA release.
In plain wordsIn horses with joint cartilage injury, SS‑31 reduced the release of mitochondrial DNA into joint fluid.
- Peptide
- Elamipretide (SS-31)
- Outcome
- DecreaseImpact-induced synovial fluid mtDNA release
- Study
equinen: not reported in source
In vivo mechanical impact of equine articular cartilage- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- Dose not stated · intraarticularAs given in this study (equine).
Source sentences
Finally, impact-induced mtDNA release was mitigated by mitoprotective treatment.
2 context sentences(design, population, supporting numbers)
In our in vivo model, one group was treated with an intraarticular injection of the mitoprotective peptide SS-31 following cartilage injury
We measured mtDNA release using four models of osteoarthritis: in vitro interleukin-1β stimulation of cultured equine chondrocytes, ex vivo mechanical impact of bovine cartilage explants, in vivo mechanical impact of equine articular cartilage, and naturally occurring equine intraarticular fracture.