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Study · Animal study (in vivo) · mouse · 2023

5 results

Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.

Campbell MD, Samuelson AT, Chiao YA, Sweetwyne MT, Ladiges WC, Rabinovitch PS, Marcinek DJ

GeroScience25 Feb 2023Cited by 5 (Europe PMC)

PMID36840897 (opens in a new tab)PMCIDPMC10651577 (opens in a new tab)DOI10.1007/s11357-023-00754-0 (opens in a new tab)PepBankPUB-36840897
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, intermittent elamipretide treatment for 8 months preserved exercise tolerance.

    In plain wordsIn aged female mice, twice-weekly elamipretide for 8 months preserved exercise tolerance.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseExercise tolerance
    Study

    mousen: not reported in source

    Aged female mice
    Outcome group
    Exercise and physical function · Aging and longevity
    Studied dose
    Dose not stated · injection · 8 monthsAs given in this study (mouse).

    Source sentences

    Summary
    We found that intermittent treatment with elamipretide for 8 months preserved exercise tolerance and left ventricular mass in mice with modest protection of diastolic function and skeletal muscle force production but did not affect kidney function as previously reported using continuous treatment.
    1 context sentence
    Summary · context
    This study tested whether twice weekly intermittent injections of elamipretide could recapitulate the same functional improvements as continuous long-term infusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, intermittent elamipretide treatment for 8 months preserved left ventricular mass.

    In plain wordsIn aged female mice, twice-weekly elamipretide for 8 months preserved heart muscle mass.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedLeft ventricular mass
    Study

    mousen: not reported in source

    Aged female mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · injection · 8 monthsAs given in this study (mouse).

    Source sentences

    Summary
    We found that intermittent treatment with elamipretide for 8 months preserved exercise tolerance and left ventricular mass in mice with modest protection of diastolic function and skeletal muscle force production but did not affect kidney function as previously reported using continuous treatment.
    1 context sentence
    Summary · context
    This study tested whether twice weekly intermittent injections of elamipretide could recapitulate the same functional improvements as continuous long-term infusion.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, intermittent elamipretide treatment gave modest protection of diastolic function.

    In plain wordsIn aged female mice, twice-weekly elamipretide gave modest protection of the heart's relaxation function.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiastolic function
    Study

    mousen: not reported in source

    Aged female mice
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · injection · 8 monthsAs given in this study (mouse).

    Source sentences

    Summary
    We found that intermittent treatment with elamipretide for 8 months preserved exercise tolerance and left ventricular mass in mice with modest protection of diastolic function and skeletal muscle force production but did not affect kidney function as previously reported using continuous treatment.
    1 context sentence
    Summary · context
    This study tested whether twice weekly intermittent injections of elamipretide could recapitulate the same functional improvements as continuous long-term infusion.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, intermittent elamipretide treatment gave modest protection of skeletal muscle force production.

    In plain wordsIn aged female mice, twice-weekly elamipretide gave modest protection of muscle strength.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSkeletal muscle force production
    Study

    mousen: not reported in source

    Aged female mice
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated · injection · 8 monthsAs given in this study (mouse).

    Source sentences

    Summary
    We found that intermittent treatment with elamipretide for 8 months preserved exercise tolerance and left ventricular mass in mice with modest protection of diastolic function and skeletal muscle force production but did not affect kidney function as previously reported using continuous treatment.
    1 context sentence
    Summary · context
    This study tested whether twice weekly intermittent injections of elamipretide could recapitulate the same functional improvements as continuous long-term infusion.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged female mice, intermittent elamipretide treatment did not affect kidney function.

    In plain wordsIn aged female mice, twice-weekly elamipretide did not change kidney function.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeKidney function
    Study

    mousen: not reported in source

    Aged female mice
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · injection · 8 monthsAs given in this study (mouse).

    Source sentences

    Summary
    We found that intermittent treatment with elamipretide for 8 months preserved exercise tolerance and left ventricular mass in mice with modest protection of diastolic function and skeletal muscle force production but did not affect kidney function as previously reported using continuous treatment.
    1 context sentence
    Summary · context
    This study tested whether twice weekly intermittent injections of elamipretide could recapitulate the same functional improvements as continuous long-term infusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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