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Study · Animal study (in vivo) · mouse · 2019

9 results

Protective effect of the antioxidative peptide SS31 on ionizing radiation-induced hematopoietic system damage in mice.

Han X, Gao P, Zhang Y, Wang J, Sun F, Liu Q, Zhang S

Blood cells, molecules & diseases7 Apr 2019Cited by 8 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In lethally irradiated mice, SS31 at 6 mg/kg raised the survival rate.

    In plain wordsIn mice exposed to lethal radiation, SS31 raised the survival rate.

    Outcome
    IncreaseSurvival of lethally irradiated mice
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Mortality · Whole body
    Studied dose
    6 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    treatment with 6 mg/kg SS31 elevated the survival rate of lethally irradiated mice
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to 4 Gy whole-body irradiation, SS31 at 6 mg/kg increased white blood cell numbers.

    In plain wordsIn irradiated mice, SS31 increased white blood cell numbers.

    Outcome
    IncreaseWhite blood cell count after 4 Gy irradiation
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    6 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    treatment with 6 mg/kg SS31 elevated the survival rate of lethally irradiated mice and increased the numbers of white blood cells, red blood cells, hemoglobin and platelets in mice exposed to 4 Gy whole-body irradiation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to 4 Gy whole-body irradiation, SS31 at 6 mg/kg increased red blood cell numbers.

    In plain wordsIn irradiated mice, SS31 increased red blood cell numbers.

    Outcome
    IncreaseRed blood cell count after 4 Gy irradiation
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    6 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    treatment with 6 mg/kg SS31 elevated the survival rate of lethally irradiated mice and increased the numbers of white blood cells, red blood cells, hemoglobin and platelets in mice exposed to 4 Gy whole-body irradiation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to 4 Gy whole-body irradiation, SS31 at 6 mg/kg increased hemoglobin.

    In plain wordsIn irradiated mice, SS31 increased hemoglobin.

    Outcome
    IncreaseHemoglobin after 4 Gy irradiation
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    6 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    treatment with 6 mg/kg SS31 elevated the survival rate of lethally irradiated mice and increased the numbers of white blood cells, red blood cells, hemoglobin and platelets in mice exposed to 4 Gy whole-body irradiation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice exposed to 4 Gy whole-body irradiation, SS31 at 6 mg/kg increased platelet numbers.

    In plain wordsIn irradiated mice, SS31 increased platelet numbers.

    Outcome
    IncreasePlatelet count after 4 Gy irradiation
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    6 mg/kgAs given in this study (mouse).

    Source sentences

    Summary
    treatment with 6 mg/kg SS31 elevated the survival rate of lethally irradiated mice and increased the numbers of white blood cells, red blood cells, hemoglobin and platelets in mice exposed to 4 Gy whole-body irradiation.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, SS31 administration improved the number of hematopoietic stem/progenitor cells.

    In plain wordsIn irradiated mice, SS31 increased the number of blood-forming stem and progenitor cells.

    Outcome
    IncreaseHematopoietic stem/progenitor cell number
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 administration improved the number of hematopoietic stem/progenitor cells (HSPCs) and the self-renewal and reconstitution abilities of these cells in irradiated mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, SS31 administration improved the self-renewal ability of hematopoietic stem/progenitor cells.

    In plain wordsIn irradiated mice, SS31 improved the self-renewal ability of blood-forming stem cells.

    Outcome
    IncreaseHSPC self-renewal ability
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS31 administration improved the number of hematopoietic stem/progenitor cells (HSPCs) and the self-renewal and reconstitution abilities of these cells in irradiated mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, SS31 administration improved the reconstitution ability of hematopoietic stem/progenitor cells.

    In plain wordsIn irradiated mice, SS31 improved the ability of blood-forming stem cells to rebuild blood.

    Outcome
    IncreaseHSPC reconstitution ability
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, SS31 administration improved the number of hematopoietic stem/progenitor cells (HSPCs) and the self-renewal and reconstitution abilities of these cells in irradiated mice.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, SS31 reduced the ROS level in hematopoietic stem/progenitor cells.

    In plain wordsIn irradiated mice, SS31 lowered reactive oxygen species in blood-forming stem cells.

    Outcome
    DecreaseROS level in HSPCs
    Study

    mousen: not reported in source

    Irradiated mice
    Outcome group
    Mitochondrial function · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 can effectively reduce the ROS level in HSPCs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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