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Study · Animal study (in vivo) · rat · 2018

4 results

Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides.

Liu ZR, Chen SQ, Zou YW, Wu XY, Li HY, Wang XQ, Shi Y, Niu HX

Free radical research1 May 2018Cited by 13 (Europe PMC)

PMID29781318 (opens in a new tab)DOI10.1080/10715762.2018.1457789 (opens in a new tab)PepBankPUB-29781318
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ureter obstruction challenged with HOCl-albumin, SS‑31 prevented the exacerbation of fibrotic changes.

    In plain wordsIn rats with a blocked ureter, SS‑31 prevented the extra kidney scarring caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInterstitial fibrosis markers (collagen-I, fibronectin, alpha-SMA)
    Study

    ratn: not reported in source

    Unilateral ureter obstruction (UUO) with HOCl-rat serum albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HOCl-RSA challenge further exacerbated the above biological effects in UUO animals, but these effects were prevented by administration of SS-31.
    2 context sentences
    Summary · context
    Compared with the control group, UUO animals displayed fibrotic abnormalities, accompanied by increased expression of collagen-I, fibronectin, α-SMA protein and mRNA in the renal interstitium.
    Summary · context
    Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with ureter obstruction challenged with HOCl-albumin, SS‑31 prevented the exacerbation of oxidative stress.

    In plain wordsIn rats with a blocked ureter, SS‑31 prevented the extra oxidative stress caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress (HOCl-alb, TBARS, mitochondrial ROS, MnSOD)
    Study

    ratn: not reported in source

    Unilateral ureter obstruction (UUO) with HOCl-rat serum albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HOCl-RSA challenge further exacerbated the above biological effects in UUO animals, but these effects were prevented by administration of SS-31.
    2 context sentences
    Summary · context
    They also displayed oxidative stress, as evidenced by increased levels of HOCl-alb, TBARS, and mitochondrial reactive oxygen species (ROS) and a decrease in MnSOD activity in the renal homogenate.
    Summary · context
    Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with ureter obstruction challenged with HOCl-albumin, SS‑31 prevented the exacerbation of mitochondrial structural and functional damage.

    In plain wordsIn rats with a blocked ureter, SS‑31 prevented the extra mitochondrial damage caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial damage (MMP, ATP, mtDNA, cytochrome C release)
    Study

    ratn: not reported in source

    Unilateral ureter obstruction (UUO) with HOCl-rat serum albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HOCl-RSA challenge further exacerbated the above biological effects in UUO animals, but these effects were prevented by administration of SS-31.
    2 context sentences
    Summary · context
    Damage to mitochondrial structure and functions was observed, as evidenced by a decrease in the mitochondrial membrane potential (MMP), ATP production, mtDNA copy number alterations and release of cytochrome C (cyto C) from the mitochondria to the cytoplasm.
    Summary · context
    Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with ureter obstruction challenged with HOCl-albumin, SS‑31 prevented the exacerbation of caspase activation and tubular cell apoptosis.

    In plain wordsIn rats with a blocked ureter, SS‑31 prevented the extra kidney cell death caused by modified albumin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTubular cell apoptosis (caspases, PARP-1, apoptotic cells)
    Study

    ratn: not reported in source

    Unilateral ureter obstruction (UUO) with HOCl-rat serum albumin challenge
    Comparator
    HOCl-RSA without SS-31
    Outcome group
    Cell viability and death · Kidney and urinary
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    HOCl-RSA challenge further exacerbated the above biological effects in UUO animals, but these effects were prevented by administration of SS-31.
    2 context sentences
    Summary · context
    These changes were accompanied by activation of caspase-3, caspase-7, caspase-9, and PARP-1 and increased apoptotic cells in the proximal tubules.
    Summary · context
    Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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