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Study · Animal study (in vivo) · mouse · 2024

8 results

SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway.

Luo P, Gu Q, Wang J, Li X, Li N, Yang W, Meng X, Zhao M

European journal of medical research29 Nov 2024Cited by 9 (Europe PMC)

PMID39609864 (opens in a new tab)PMCIDPMC11605876 (opens in a new tab)DOI10.1186/s40001-024-02169-9 (opens in a new tab)PepBankPUB-39609864
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, SS31 inhibited the expression of IL-6.

    In plain wordsIn mice with lung injury, SS31 lowered the level of the inflammatory signal IL-6.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-6 expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study demonstrated that SS31 can inhibit the expression of inflammatory factors IL-6, IL-1β, IL-18, and TNF-α, and reduce the expression of pyroptosis-related proteins NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, SS31 inhibited the expression of IL-1beta.

    In plain wordsIn mice with lung injury, SS31 lowered the level of the inflammatory signal IL-1beta.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-1beta expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study demonstrated that SS31 can inhibit the expression of inflammatory factors IL-6, IL-1β, IL-18, and TNF-α, and reduce the expression of pyroptosis-related proteins NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, SS31 inhibited the expression of IL-18.

    In plain wordsIn mice with lung injury, SS31 lowered the level of the inflammatory signal IL-18.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIL-18 expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study demonstrated that SS31 can inhibit the expression of inflammatory factors IL-6, IL-1β, IL-18, and TNF-α, and reduce the expression of pyroptosis-related proteins NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, SS31 inhibited the expression of TNF-alpha.

    In plain wordsIn mice with lung injury, SS31 lowered the level of the inflammatory signal TNF-alpha.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTNF-alpha expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study demonstrated that SS31 can inhibit the expression of inflammatory factors IL-6, IL-1β, IL-18, and TNF-α, and reduce the expression of pyroptosis-related proteins NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, SS31 reduced the expression of the pyroptosis-related protein NLRP3.

    In plain wordsIn mice with lung injury, SS31 lowered the level of NLRP3, a protein linked to inflammatory cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNLRP3 expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study demonstrated that SS31 can inhibit the expression of inflammatory factors IL-6, IL-1β, IL-18, and TNF-α, and reduce the expression of pyroptosis-related proteins NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, SS31 reduced the expression of the pyroptosis-related protein GSDMD-N.

    In plain wordsIn mice with lung injury, SS31 lowered the level of GSDMD-N, a protein linked to inflammatory cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseGSDMD-N expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This study demonstrated that SS31 can inhibit the expression of inflammatory factors IL-6, IL-1β, IL-18, and TNF-α, and reduce the expression of pyroptosis-related proteins NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with LPS-induced acute lung injury, LPS increased S100A8 expression and SS31 decreased it.

    In plain wordsIn mice with lung injury, SS31 lowered the level of S100A8, which LPS had raised.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseS100A8 expression
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    LPS stimulation leads to increased expression of S100A8, while SS31 decreases its expression.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In the acute lung injury model, recombinant S100A8 attenuated the inhibitory effect of SS31 on IL-1beta, IL-18, NLRP3 and GSDMD-N.

    In plain wordsIn mice with lung injury, adding S100A8 protein weakened the anti-inflammatory effect of SS31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableEffect of recombinant S100A8 on SS31 inhibition of IL-1beta, IL-18, NLRP3 and GSDMD-N
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Recombinant protein S100A8 can attenuate the inhibitory effect of SS31 on IL-1β, IL-18, NLRP3, and GSDMD-N.
    1 context sentence
    Summary · context
    This article validates the role of SS31 in lipopolysaccharide (LPS)-induced ALI.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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