Skip to content

Study · Animal study (in vivo) · rat · 2021

4 results

Role of AQP3 in the Vascular Leakage of Sepsis and the Protective Effect of Ss-31.

Zhang J, Wang P, Wu Y, Zhu Y, Peng XY, Xiang XM, Xue MY, Li QH, Li JX, Yan QG, Liu LM, Li T

Journal of cardiovascular pharmacology1 Aug 2021Cited by 7 (Europe PMC)

PMID34050090 (opens in a new tab)DOI10.1097/fjc.0000000000001050 (opens in a new tab)PepBankPUB-34050090
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In a sepsis study using septic rats and LPS-treated pulmonary vein endothelial cells, the antioxidant Ss‑31 decreased the expression of AQP3.

    In plain wordsIn a sepsis study in rats and cultured cells, Ss‑31 lowered the amount of the water channel protein AQP3.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAQP3 expression
    Study

    ratn: not reported in source

    Septic rats (cecum ligation perforation) or LPS-treated pulmonary vein endothelial cells; the abstract does not say which
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Antioxidant Ss-31 decreased the expression of AQP3
    1 context sentence
    Summary · context
    Using the cecum ligation perforation-induced septic rat and LPS-treated pulmonary vein endothelial cells, the role of AQPs in the regulation of the permeability of pulmonary vascular and its relationship to Ss-31 were studied.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In a sepsis study using septic rats and LPS-treated pulmonary vein endothelial cells, the antioxidant Ss‑31 decreased reactive oxygen species levels.

    In plain wordsIn a sepsis study in rats and cultured cells, Ss‑31 lowered levels of harmful reactive oxygen molecules.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseROS levels
    Study

    ratn: not reported in source

    Septic rats (cecum ligation perforation) or LPS-treated pulmonary vein endothelial cells; the abstract does not say which
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and ROS levels.
    1 context sentence
    Summary · context
    Using the cecum ligation perforation-induced septic rat and LPS-treated pulmonary vein endothelial cells, the role of AQPs in the regulation of the permeability of pulmonary vascular and its relationship to Ss-31 were studied.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In septic rats, Ss‑31 improved pulmonary vascular permeability.

    In plain wordsIn rats with sepsis, Ss‑31 improved how leaky the lung blood vessels were.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePulmonary vascular permeability
    Study

    ratn: not reported in source

    Cecum ligation perforation-induced sepsis
    Outcome group
    Vascular function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ss-31 improved pulmonary vascular permeability
    1 context sentence
    Summary · context
    Using the cecum ligation perforation-induced septic rat and LPS-treated pulmonary vein endothelial cells, the role of AQPs in the regulation of the permeability of pulmonary vascular and its relationship to Ss-31 were studied.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In septic rats, Ss‑31 prolonged survival.

    In plain wordsIn rats with sepsis, Ss‑31 helped the rats live longer.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSurvival of septic rats
    Study

    ratn: not reported in source

    Cecum ligation perforation-induced sepsis
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    prolonged survival of sepsis rats.
    1 context sentence
    Summary · context
    Using the cecum ligation perforation-induced septic rat and LPS-treated pulmonary vein endothelial cells, the role of AQPs in the regulation of the permeability of pulmonary vascular and its relationship to Ss-31 were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.