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Study · Animal study (in vivo) · zebrafish · 2018

3 results

A mitochondrial targeting tetrapeptide Bendavia protects lateral line hair cells from gentamicin exposure.

Kuang X, Sun Y, Wang Z, Zhou S, Liu H

Journal of applied toxicology : JAT3 Nov 2017Cited by 6 (Europe PMC)

PMID29105116 (opens in a new tab)DOI10.1002/jat.3547 (opens in a new tab)PepBankPUB-29105116
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish lateral lines, Bendavia pretreatment protected hair cells from gentamicin in a dose-dependent way in acute and chronic exposure.

    In plain wordsIn zebrafish, Bendavia protected ear hair cells from gentamicin, with more protection at higher doses.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHair cell protection against gentamicin, acute and chronic
    Study

    zebrafishn: not reported in source

    Zebrafish lateral line gentamicin hair cell damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results demonstrated the pretreatment of Bendavia exhibited dose-dependent protection against gentamicin in both acute and chronic exposure.
    1 context sentence
    Summary · context
    The aim of the present study is therefore to evaluate the protective effect of Bendavia, a novel antioxidant, on gentamicin-induced hair cell damage in zebrafish lateral lines.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In zebrafish lateral lines, Bendavia at 150 μm gave optimal protection against acute or chronic gentamicin exposure.

    In plain wordsIn zebrafish, Bendavia gave the best hair cell protection at 150 μm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseOptimal hair cell protection concentration
    Study

    zebrafishn: not reported in source

    Zebrafish lateral line gentamicin hair cell damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    150 μmAs given in this study (zebrafish).

    Measurements

    Optimal protective concentration
    150 μm
    zebrafish lateral line

    Source sentences

    Summary
    We found that Bendavia at 150 μm conferred optimal protection from either acute or chronic exposure with ototoxin.
    1 context sentence
    Summary · context
    The aim of the present study is therefore to evaluate the protective effect of Bendavia, a novel antioxidant, on gentamicin-induced hair cell damage in zebrafish lateral lines.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In zebrafish lateral lines, Bendavia reduced uptake of fluorescent-tagged gentamicin through mechanoelectrical transduction channels.

    In plain wordsIn zebrafish, Bendavia reduced how much gentamicin entered hair cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseFluorescent gentamicin uptake via MET channels
    Study

    zebrafishn: not reported in source

    Zebrafish lateral line gentamicin hair cell damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bendavia reduced uptake of fluorescent-tagged gentamicin via mechanoelectrical transduction channels, suggesting its protective effects may be partially due to decreasing ototoxic molecule uptake.
    1 context sentence
    Summary · context
    The aim of the present study is therefore to evaluate the protective effect of Bendavia, a novel antioxidant, on gentamicin-induced hair cell damage in zebrafish lateral lines.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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