[Protective effect of mitochondria-targeted antioxidant SS31 on early brain injury following subarachnoid hemorrhage in rats].

Zhou J, Li Z, Chen Z, Yang K

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences1 Sept 2017Cited by 2 (Europe PMC)

PMID28989143DOI10.11817/j.issn.1672-7347.2017.09.002PepBankPUB-28989143

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 reduced cortical MDA levels compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 reduced a marker of oxidative damage in the cortex compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseCortical malondialdehyde (MDA)
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Treatment with SS31 could significantly reduce MDA levels, and restored the activities of GPx and SOD in the cortex following SAH when compared with the SAH+V group.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 restored cortical GPx activity compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 restored an antioxidant enzyme in the cortex compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCortical glutathione peroxidase activity
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Treatment with SS31 could significantly reduce MDA levels, and restored the activities of GPx and SOD in the cortex following SAH when compared with the SAH+V group.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 restored cortical SOD activity compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 restored an antioxidant enzyme in the cortex compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCortical superoxide dismutase activity
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Treatment with SS31 could significantly reduce MDA levels, and restored the activities of GPx and SOD in the cortex following SAH when compared with the SAH+V group.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914303
04AnimalAnimal study (in vivo)Mechanism
In rats with subarachnoid hemorrhage, SS31 increased mitochondrial cytochrome c levels.
In plain wordsIn rats with brain bleeding, SS31 increased cytochrome c in mitochondria.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial cytochrome c
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS31 trearment increased or decreased the levels of mitochondrial Cyt C or Bax, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914304
05AnimalAnimal study (in vivo)Mechanism
In rats with subarachnoid hemorrhage, SS31 decreased mitochondrial Bax levels.
In plain wordsIn rats with brain bleeding, SS31 decreased Bax in mitochondria.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMitochondrial Bax
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
SS31 trearment increased or decreased the levels of mitochondrial Cyt C or Bax, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914305
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 ameliorated brain edema at 24 h compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 reduced brain swelling at 24 hours compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseBrain edema
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914306
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 ameliorated Evans blue dye extravasation at 24 h compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 reduced leakage across the blood-brain barrier at 24 hours compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseBlood-brain barrier permeability (Evans blue extravasation)
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914307
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 improved neurological deficits at 24 h compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 improved neurological deficits at 24 hours compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseNeurological deficit score
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914308
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with subarachnoid hemorrhage, SS31 decreased neuronal apoptosis at 24 h compared with the SAH+vehicle group.
In plain wordsIn rats with brain bleeding, SS31 decreased nerve cell death at 24 hours compared with vehicle.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseNeuronal apoptosis
Study
ratn: not reported in source
Subarachnoid hemorrhage (prechiasmatic cistern) early brain injury
Comparator
SAH+vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Moreover, SS31 treatment ameliorated brain edema and Evans blue dye extravasation, improved neurological deficits, and decreased neuronal apoptosis at 24 h after SAH.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 96 Sprague-Dawley rats were randomly divided into 4 groups: A sham group, an SAH group, an SAH+vehicle group (SAH+V), and an SAH+SS31 group.
Summary · context
The SS31 (5 mg/kg) as well as equal volume of vehicle were administrated intraperitoneally at 2 h after SAH.
Report a problemFND-2898914309

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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