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Study · Animal study (in vivo) · mouse · 2022

3 results

Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption.

Valencia AP, Whitson JA, Wang S, Nguyen L, den Hartigh LJ, Rabinovitch PS, Marcinek DJ

Nutrients3 Nov 2022Cited by 5 (Europe PMC)

PMID36364920 (opens in a new tab)PMCIDPMC9655368 (opens in a new tab)DOI10.3390/nu14214645 (opens in a new tab)PepBankPUB-36364920
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Summary

Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., cardiac remodeling and sarcopenia). We tested whether HS diet (60%kcal sucrose) would accelerate muscle dysfunction in 24-month-old male CB6F1 mice. By week 1 on HS diet, mice developed significant cardiac hypertrophy compared to age-matched chow-fed controls. The increased weight of the heart persisted throughout the 4-week treatment, while body weight and strength declined more rapidly than controls. We then tested whether HS diet could worsen cardiac dysfunction in old mice and if the mitochondrial-targeted drug, elamipretide (ELAM), could prevent the diet-induced effect. Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week. As demonstrated in the previous experiment, old mice had age-related cardiac hypertrophy that worsened after one week on HS and was prevented by ELAM treatment, while the HS diet had no detectable effect on hypertrophy in the young mice. As expected, mitochondrial respiration and reactive oxygen species (ROS) production were altered by age, but were not significantly affected by HS diet or ELAM. Our findings highlight the vulnerability of the aged heart to HS diet that can be prevented by systemic targeting of the mitochondria with ELAM.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old mice, elamipretide prevented the worsening of cardiac hypertrophy caused by one week of high-sucrose diet.

    In plain wordsIn old mice, elamipretide prevented the heart enlargement that a high-sugar diet made worse.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiet-induced cardiac hypertrophy in old mice
    Study

    mousen: not reported in source

    old and young mice on high-sucrose diet
    Comparator
    Saline
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    As demonstrated in the previous experiment, old mice had age-related cardiac hypertrophy that worsened after one week on HS and was prevented by ELAM treatment, while the HS diet had no detectable effect on hypertrophy in the young mice.
    1 context sentence
    Summary · context
    Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, mitochondrial respiration was altered by age but was not significantly affected by elamipretide.

    In plain wordsIn mice, elamipretide did not significantly change mitochondrial respiration.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeMitochondrial respiration
    Study

    mousen: not reported in source

    old and young mice on high-sucrose diet
    Comparator
    Saline
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    mitochondrial respiration and reactive oxygen species (ROS) production were altered by age, but were not significantly affected by HS diet or ELAM
    1 context sentence
    Summary · context
    Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, reactive oxygen species production was altered by age but was not significantly affected by elamipretide.

    In plain wordsIn mice, elamipretide did not significantly change production of reactive oxygen species.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeReactive oxygen species production
    Study

    mousen: not reported in source

    old and young mice on high-sucrose diet
    Comparator
    Saline
    Outcome group
    Mitochondrial function · Aging and longevity
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    mitochondrial respiration and reactive oxygen species (ROS) production were altered by age, but were not significantly affected by HS diet or ELAM
    1 context sentence
    Summary · context
    Old and young mice were treated with either ELAM or saline as a control for 2 weeks, and provided with HS diet or chow on the last week.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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