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Study · Animal study (in vivo) · mouse · 2023

11 results

Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm: Crosstalk with endoplasmic reticulum stress.

Navas-Madroñal M, Almendra-Pegueros R, Puertas-Umbert L, Jiménez-Altayó F, Julve J, Pérez B, Consegal-Pérez M, Kassan M, Martínez-González J, Rodriguez C, Galán M

British journal of pharmacology25 Apr 2023Cited by 14 (Europe PMC)

PMID36964990 (opens in a new tab)DOI10.1111/bph.16077 (opens in a new tab)PepBankPUB-36964990
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 ameliorated mitochondrial dysfunction triggered by Ang II.

    In plain wordsIn mice, SS31 reduced mitochondrial damage caused by angiotensin II.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitochondria-targeted tetrapeptide, Szeto-Schiller 31 (SS31), ameliorated mitochondrial dysfunction and the enhanced expression of ER stress markers triggered by Ang II in ApoE-/- mice, and limited plasmatic and vascular reactive oxygen species (ROS) levels.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 reduced the enhanced expression of ER stress markers.

    In plain wordsIn mice, SS31 lowered markers of endoplasmic reticulum stress raised by angiotensin II.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseER stress marker expression
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitochondria-targeted tetrapeptide, Szeto-Schiller 31 (SS31), ameliorated mitochondrial dysfunction and the enhanced expression of ER stress markers triggered by Ang II in ApoE-/- mice, and limited plasmatic and vascular reactive oxygen species (ROS) levels.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 limited plasmatic and vascular reactive oxygen species levels.

    In plain wordsIn mice, SS31 lowered reactive oxygen species in blood and blood vessels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePlasma and vascular ROS
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitochondria-targeted tetrapeptide, Szeto-Schiller 31 (SS31), ameliorated mitochondrial dysfunction and the enhanced expression of ER stress markers triggered by Ang II in ApoE-/- mice, and limited plasmatic and vascular reactive oxygen species (ROS) levels.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In Ang II-infused ApoE-/- mice, SS31 improved survival.

    In plain wordsIn mice, SS31 improved survival.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSurvival
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, SS31 improved survival, reduced the incidence and severity of abdominal aortic aneurysm (AAA), and the Ang II-induced increase in aortic diameter as evaluated by ultrasonography, resembling the response triggered by the classic ER stress inhibitors tauroursodeoxycholic acid (TUDCA) an…
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In Ang II-infused ApoE-/- mice, SS31 reduced the incidence of abdominal aortic aneurysm.

    In plain wordsIn mice, SS31 lowered how often abdominal aortic aneurysm occurred.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAAA incidence
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, SS31 improved survival, reduced the incidence and severity of abdominal aortic aneurysm (AAA), and the Ang II-induced increase in aortic diameter as evaluated by ultrasonography, resembling the response triggered by the classic ER stress inhibitors tauroursodeoxycholic acid (TUDCA) an…
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In Ang II-infused ApoE-/- mice, SS31 reduced the severity of abdominal aortic aneurysm.

    In plain wordsIn mice, SS31 made abdominal aortic aneurysm less severe.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAAA severity
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, SS31 improved survival, reduced the incidence and severity of abdominal aortic aneurysm (AAA), and the Ang II-induced increase in aortic diameter as evaluated by ultrasonography, resembling the response triggered by the classic ER stress inhibitors tauroursodeoxycholic acid (TUDCA) an…
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In Ang II-infused ApoE-/- mice, SS31 reduced the Ang II-induced increase in aortic diameter.

    In plain wordsIn mice, SS31 reduced the widening of the aorta caused by angiotensin II.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAortic diameter by ultrasonography
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, SS31 improved survival, reduced the incidence and severity of abdominal aortic aneurysm (AAA), and the Ang II-induced increase in aortic diameter as evaluated by ultrasonography, resembling the response triggered by the classic ER stress inhibitors tauroursodeoxycholic acid (TUDCA) an…
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 reduced Ang II-induced disorganization of the extracellular matrix in the abdominal aorta.

    In plain wordsIn mice, SS31 reduced damage to the structure of the aortic wall.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseExtracellular matrix disorganization
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Disorganization of the extracellular matrix, increased expression of metalloproteinases and pro-inflammatory markers and infiltration of immune cells induced by Ang II in the abdominal aorta were effectively reduced by SS31 and ER inhibitors.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 reduced Ang II-induced expression of metalloproteinases in the abdominal aorta.

    In plain wordsIn mice, SS31 lowered levels of tissue-degrading enzymes in the aorta.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMetalloproteinase expression
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Disorganization of the extracellular matrix, increased expression of metalloproteinases and pro-inflammatory markers and infiltration of immune cells induced by Ang II in the abdominal aorta were effectively reduced by SS31 and ER inhibitors.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 reduced Ang II-induced expression of pro-inflammatory markers in the abdominal aorta.

    In plain wordsIn mice, SS31 lowered inflammation markers in the aorta.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePro-inflammatory marker expression
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Disorganization of the extracellular matrix, increased expression of metalloproteinases and pro-inflammatory markers and infiltration of immune cells induced by Ang II in the abdominal aorta were effectively reduced by SS31 and ER inhibitors.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In Ang II-infused ApoE-/- mice, SS31 reduced Ang II-induced infiltration of immune cells into the abdominal aorta.

    In plain wordsIn mice, SS31 reduced the number of immune cells entering the aorta.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseImmune cell infiltration
    Study

    mousen: not reported in source

    Ang II-infused ApoE-/- mice
    Outcome group
    Immune response · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Disorganization of the extracellular matrix, increased expression of metalloproteinases and pro-inflammatory markers and infiltration of immune cells induced by Ang II in the abdominal aorta were effectively reduced by SS31 and ER inhibitors.
    1 context sentence
    Summary · context
    This study determined if inhibition of mitochondrial stress reduces aneurysm development in angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE-/- ) mice and its effect on ER stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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