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Study · In vitro (cells) · 2017

3 results

Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells.

Imai T, Mishiro K, Takagi T, Isono A, Nagasawa H, Tsuruma K, Shimazawa M, Hara H

Current neurovascular research1 Jan 2017Cited by 12 (Europe PMC)

PMID27855593 (opens in a new tab)DOI10.2174/1567202614666161117110609 (opens in a new tab)PepBankPUB-27855593
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human brain microvascular endothelial cells under oxygen glucose deprivation, bendavia (SS‑31) recovered cell viability.

    In plain wordsIn lab-grown human brain blood-vessel cells under oxygen and glucose deprivation, bendavia (SS‑31) restored cell survival.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCell viability under OGD
    Study

    humann: not reported in source

    human brain microvascular endothelial cells (HBMVECs) under oxygen glucose deprivation (OGD) for 6 h
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bendavia recovered cell viability
    1 context sentence
    Summary · context
    After pre-treatment with bendavia, we exposed HBMVECs to oxygen glucose deprivation (OGD) for 6 h.
  2. 02LabIn vitro (cells)Mechanism

    In human brain microvascular endothelial cells under oxygen glucose deprivation, bendavia (SS‑31) reduced caspase-3/7 activity.

    In plain wordsIn lab-grown human brain blood-vessel cells under oxygen and glucose deprivation, bendavia (SS‑31) lowered a marker of programmed cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCaspase-3/7 activity under OGD
    Study

    humann: not reported in source

    human brain microvascular endothelial cells (HBMVECs) under oxygen glucose deprivation (OGD) for 6 h
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced the caspase-3/7 activity induced by OGDinduced damage.
    1 context sentence
    Summary · context
    After pre-treatment with bendavia, we exposed HBMVECs to oxygen glucose deprivation (OGD) for 6 h.
  3. 03LabIn vitro (cells)Mechanism

    In human brain microvascular endothelial cells under oxygen glucose deprivation, bendavia (SS‑31) recovered mitochondrial functions.

    In plain wordsIn lab-grown human brain blood-vessel cells under oxygen and glucose deprivation, bendavia (SS‑31) restored the function of the energy-producing parts (mitochondria).

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedMitochondrial function under OGD
    Study

    humann: not reported in source

    human brain microvascular endothelial cells (HBMVECs) under oxygen glucose deprivation (OGD) for 6 h
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bendavia also recovered mitochondrial functions.
    1 context sentence
    Summary · context
    After pre-treatment with bendavia, we exposed HBMVECs to oxygen glucose deprivation (OGD) for 6 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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