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Study · In vitro (cells) · pig · 2019

4 results

Renovascular disease induces mitochondrial damage in swine scattered tubular cells.

Nargesi AA, Zhu XY, Conley SM, Woollard JR, Saadiq IM, Lerman LO, Eirin A

American journal of physiology. Renal physiology28 Aug 2019Cited by 23 (Europe PMC)

PMID31461348 (opens in a new tab)PMCIDPMC6879943 (opens in a new tab)DOI10.1152/ajprenal.00276.2019 (opens in a new tab)PepBankPUB-31461348
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In STCs from pigs with renal artery stenosis, elamipretide (mitoprotection) restored mitochondrial swelling.

    In plain wordsIn pig kidney cells in the lab, elamipretide reversed mitochondrial swelling.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial swelling in STCs
    Study

    pign: not reported in source

    Isolated pig scattered tubular cells (STCs)
    Comparator
    Untreated STCs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    1 nM · incubation with cells · 6 hAs given in this study (pig).

    Source sentences

    Summary
    STCs isolated from Lean + RAS and MetS + RAS pigs showed mitochondrial swelling and decreased matrix density, which were both restored by mitoprotection.
    1 context sentence
    Summary · context
    Pig STCs were isolated and characterized, and mitochondrial structure, membrane potential, and oxidative stress were assessed in cells untreated or incubated with the mitoprotective drug elamipretide (1 nM for 6 h).
  2. 02LabIn vitro (cells)Efficacy outcome

    In STCs from pigs with renal artery stenosis, elamipretide (mitoprotection) restored decreased mitochondrial matrix density.

    In plain wordsIn pig kidney cells in the lab, elamipretide restored mitochondrial matrix density.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial matrix density in STCs
    Study

    pign: not reported in source

    Isolated pig scattered tubular cells (STCs)
    Comparator
    Untreated STCs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    1 nM · incubation with cells · 6 hAs given in this study (pig).

    Source sentences

    Summary
    STCs isolated from Lean + RAS and MetS + RAS pigs showed mitochondrial swelling and decreased matrix density, which were both restored by mitoprotection.
    1 context sentence
    Summary · context
    Pig STCs were isolated and characterized, and mitochondrial structure, membrane potential, and oxidative stress were assessed in cells untreated or incubated with the mitoprotective drug elamipretide (1 nM for 6 h).
  3. 03LabIn vitro (cells)Efficacy outcome

    In STCs from pigs with metabolic syndrome and renal artery stenosis, elamipretide improved mitochondrial structure and function.

    In plain wordsIn pig kidney cells in the lab, elamipretide improved mitochondrial structure and function.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial structure and function in MetS + RAS STCs
    Study

    pign: not reported in source

    Isolated pig scattered tubular cells (STCs)
    Comparator
    Untreated STCs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    1 nM · incubation with cells · 6 hAs given in this study (pig).

    Source sentences

    Summary
    Importantly, mitoprotection improved mitochondrial structure and function as well as the capacity of MetS + RAS STCs to repair injured tubular cells in vitro.
    1 context sentence
    Summary · context
    Pig STCs were isolated and characterized, and mitochondrial structure, membrane potential, and oxidative stress were assessed in cells untreated or incubated with the mitoprotective drug elamipretide (1 nM for 6 h).
  4. 04LabIn vitro (cells)Efficacy outcome

    In STCs from pigs with metabolic syndrome and renal artery stenosis, elamipretide improved the capacity to repair injured tubular cells in vitro.

    In plain wordsIn pig kidney cells in the lab, elamipretide improved their ability to repair injured kidney tube cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCapacity of MetS + RAS STCs to repair injured tubular cells
    Study

    pign: not reported in source

    Isolated pig scattered tubular cells (STCs)
    Comparator
    Untreated STCs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    1 nM · incubation with cells · 6 hAs given in this study (pig).

    Source sentences

    Summary
    Importantly, mitoprotection improved mitochondrial structure and function as well as the capacity of MetS + RAS STCs to repair injured tubular cells in vitro.
    2 context sentences
    Summary · context
    STC-protective effects were assessed in vitro by their capacity to proliferate and improve viability of injured pig tubular epithelial cells.
    Summary · context
    Pig STCs were isolated and characterized, and mitochondrial structure, membrane potential, and oxidative stress were assessed in cells untreated or incubated with the mitoprotective drug elamipretide (1 nM for 6 h).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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