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Study · In vitro (cells) · 2024

3 results

SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells.

Mo Y, Deng S, Ai Y, Li W

Biochemical and biophysical research communications4 Apr 2024Cited by 4 (Europe PMC)

PMID38581954 (opens in a new tab)DOI10.1016/j.bbrc.2024.149887 (opens in a new tab)PepBankPUB-38581954
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In LPS-stimulated HepG2 cells, SS‑31 promoted formation of autolysosomes and autophagosomes and facilitated autophagic flux.

    In plain wordsIn liver cells, SS‑31 increased the cell clean-up process called autophagy.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseAutophagic flux
    Study

    n: not reported in source

    LPS-stimulated HepG2 cells
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 promotes the formation of autolysosomes and autophagosomes, thereby facilitating autophagic flux to a certain degree
    1 context sentence
    Summary · context
    In our study, we investigated the impact of SS-31 on LPS-induced autophagy in HepG2 cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In LPS-stimulated HepG2 cells, SS‑31 inhibited the inflammatory response through ATG5-dependent autophagy.

    In plain wordsIn liver cells, SS‑31 reduced inflammation caused by LPS.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLPS-triggered inflammatory response
    Study

    n: not reported in source

    LPS-stimulated HepG2 cells
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In summary, our study demonstrates that SS-31 inhibits LPS-stimulated inflammation in HepG2 cells by upregulating ATG5-dependent autophagy.
    1 context sentence
    Summary · context
    In our study, we investigated the impact of SS-31 on LPS-induced autophagy in HepG2 cells.
  3. 03LabIn vitro (cells)Mechanism

    In LPS-stimulated HepG2 cells, SS‑31 increased ATG5-dependent autophagy.

    In plain wordsIn liver cells, SS‑31 raised ATG5, a protein that drives autophagy.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseATG5-dependent autophagy
    Study

    n: not reported in source

    LPS-stimulated HepG2 cells
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS-31 inhibits LPS-stimulated inflammation in HepG2 cells by upregulating ATG5-dependent autophagy
    2 context sentences
    Title · context
    SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells.
    Summary · context
    In our study, we investigated the impact of SS-31 on LPS-induced autophagy in HepG2 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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