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Study · In vitro (cells) · 2025

1 result

Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.

Vaziri N, Shutt TE, Karim W, Raedler TJ, Pantelis C, Thomas N, Jayaram M, Greenway SC, Bousman CA

Molecular psychiatry17 Feb 2025Cited by 2 (Europe PMC)

PMID39962181 (opens in a new tab)DOI10.1038/s41380-025-02935-z (opens in a new tab)PepBankPUB-39962181
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In iPSC-derived cardiomyocytes, elamipretide attenuated clozapine-induced cardiotoxic effects.

    In plain wordsIn lab tests on heart cells grown from stem cells, elamipretide reduced heart cell damage caused by clozapine.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseClozapine-induced cardiotoxic effects
    Study

    humann: not reported in source

    iPSC-derived cardiomyocytes from patients with schizophrenia
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, pharmacological targeting of the mitochondria (elamipretide) and inflammasome (ustekinumab) attenuated these clozapine-induced cardiotoxic effects.
    1 context sentence
    Summary · context
    In this study, cardiomyocytes that were derived from induced pluripotent stem cells generated from four patients with treatment-resistant schizophrenia with (n = 2) and without (n = 2) a history of clozapine-induced myocarditis were used to assess mitochondria- and NLRP3 inflammasome-mediated mechan…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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