Skip to content

Study · In vitro (cells) · mouse · 2016

3 results

Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction.

Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA

American journal of physiology. Lung cellular and molecular physiology11 Mar 2016Cited by 26 (Europe PMC)

PMID26968769 (opens in a new tab)PMCIDPMC4896095 (opens in a new tab)DOI10.1152/ajplung.00312.2015 (opens in a new tab)PepBankPUB-26968769
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In C2C12 muscle cells, SS31 blocked the cytomix-induced increase in superoxide generation (P < 0.001).

    In plain wordsIn lab-grown muscle cells, SS31 blocked a rise in harmful oxygen molecules caused by inflammatory signals.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial superoxide generation
    Study

    mousen: not reported in source

    C2C12 skeletal muscle cells treated with cytomix
    Comparator
    Cytomix alone
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    10 μg/mlAs given in this study (mouse).

    Source sentences

    Summary
    AACOCF3 and SS31 blocked increases in superoxide generation (P < 0.001).
    1 context sentence
    Summary · context
    We also determined if SS31 (10 μg/ml), a mitochondrial superoxide scavenger, reduced cytomix-mediated calpain activation.
  2. 02LabIn vitro (cells)Mechanism

    In C2C12 muscle cells, SS31 prevented cytomix-induced calpain activation.

    In plain wordsIn lab-grown muscle cells, SS31 prevented the switching on of a muscle-damaging enzyme caused by inflammatory signals.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCalpain activity
    Study

    mousen: not reported in source

    C2C12 skeletal muscle cells treated with cytomix
    Comparator
    Cytomix alone
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 μg/mlAs given in this study (mouse).

    Source sentences

    Summary
    Cytomix also activated calpain (P < 0.001) and inactivated calpastatin (P < 0.01); both AACOCF3 and SS31 prevented these changes.
    1 context sentence
    Summary · context
    We also determined if SS31 (10 μg/ml), a mitochondrial superoxide scavenger, reduced cytomix-mediated calpain activation.
  3. 03LabIn vitro (cells)Mechanism

    In C2C12 muscle cells, SS31 prevented cytomix-induced inactivation of calpastatin.

    In plain wordsIn lab-grown muscle cells, SS31 prevented loss of a natural brake on a muscle-damaging enzyme.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCalpastatin activity
    Study

    mousen: not reported in source

    C2C12 skeletal muscle cells treated with cytomix
    Comparator
    Cytomix alone
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    10 μg/mlAs given in this study (mouse).

    Source sentences

    Summary
    Cytomix also activated calpain (P < 0.001) and inactivated calpastatin (P < 0.01); both AACOCF3 and SS31 prevented these changes.
    1 context sentence
    Summary · context
    We also determined if SS31 (10 μg/ml), a mitochondrial superoxide scavenger, reduced cytomix-mediated calpain activation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.