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Study · In vitro (cells) · 2022

2 results

A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics.

Peng X, Zhang C, Zhou ZM, Wang K, Gao JW, Qian ZY, Bao JP, Ji HY, Cabral VLF, Wu XT

Inflammation research : official journal of the European Histamine Research Society ... [et al.]15 Apr 2022Cited by 36 (Europe PMC)

PMID35426501 (opens in a new tab)DOI10.1007/s00011-022-01570-6 (opens in a new tab)PepBankPUB-35426501
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In nucleus pulposus cells treated with LPS, SS‑31 inhibited pyroptosis.

    In plain wordsIn lab-grown disc cells treated with LPS, SS‑31 reduced a form of inflammatory cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLPS-induced pyroptosis
    Study

    n: not reported in source

    Nucleus pulposus cells induced by lipopolysaccharide
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitochondria-targeted active peptide SS-31 inhibited LPS-induced pyroptosis and ROS production in NP cells.
    1 context sentence
    Summary · context
    NP cells induced by LPS were used as an in vitro model of the inflammatory environment of the intervertebral disc.
  2. 02LabIn vitro (cells)Efficacy outcome

    In nucleus pulposus cells treated with LPS, SS‑31 inhibited ROS production.

    In plain wordsIn lab-grown disc cells treated with LPS, SS‑31 reduced production of reactive oxygen species.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLPS-induced ROS production
    Study

    n: not reported in source

    Nucleus pulposus cells induced by lipopolysaccharide
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The mitochondria-targeted active peptide SS-31 inhibited LPS-induced pyroptosis and ROS production in NP cells.
    1 context sentence
    Summary · context
    NP cells induced by LPS were used as an in vitro model of the inflammatory environment of the intervertebral disc.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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