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Study · In vitro (cells) · mouse · 2015

3 results

SS-31 attenuates TNF-α induced cytokine release from C2C12 myotubes.

Lightfoot AP, Sakellariou GK, Nye GA, McArdle F, Jackson MJ, Griffiths RD, McArdle A

Redox biology10 Aug 2015Cited by 36 (Europe PMC)

PMID26291279 (opens in a new tab)PMCIDPMC4556772 (opens in a new tab)DOI10.1016/j.redox.2015.08.007 (opens in a new tab)PepBankPUB-26291279
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In C2C12 myotubes, pre-treatment with SS‑31 attenuated the TNF-α-induced rise in superoxide.

    In plain wordsIn muscle cells in lab tests, SS‑31 pre-treatment reduced the superoxide rise caused by TNF-α.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTNF-α-induced mitochondrial superoxide
    Study

    mousen: not reported in source

    C2C12 myotubes treated with TNF-α
    Comparator
    TNF-α without SS-31
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide
    1 context sentence
    Summary · context
    An increase was also seen in superoxide in response to treatment with TNF-α, which was localised to the mitochondria and this was also associated with activation of NF-κB.
  2. 02LabIn vitro (cells)Mechanism

    In C2C12 myotubes, pre-treatment with SS‑31 attenuated the TNF-α-induced activation of NF-κB.

    In plain wordsIn muscle cells in lab tests, SS‑31 pre-treatment reduced NF-κB activation caused by TNF-α.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTNF-α-induced NF-κB activation
    Study

    mousen: not reported in source

    C2C12 myotubes treated with TNF-α
    Comparator
    TNF-α without SS-31
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide
    1 context sentence
    Summary · context
    An increase was also seen in superoxide in response to treatment with TNF-α, which was localised to the mitochondria and this was also associated with activation of NF-κB.
  3. 03LabIn vitro (cells)Mechanism

    In C2C12 myotubes, pre-treatment with SS‑31 attenuated the TNF-α-induced release of myokines.

    In plain wordsIn muscle cells in lab tests, SS‑31 pre-treatment reduced the release of muscle signaling proteins caused by TNF-α.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseTNF-α-induced myokine release
    Study

    mousen: not reported in source

    C2C12 myotubes treated with TNF-α
    Comparator
    TNF-α without SS-31
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The changes in superoxide, activation of NF-kB and release of myokines were attenuated following pre-treatment with SS-31 peptide
    1 context sentence
    Summary · context
    An increase was also seen in superoxide in response to treatment with TNF-α, which was localised to the mitochondria and this was also associated with activation of NF-κB.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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