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Study · In vitro (cells) · 2011

7 results

Mitochondria-targeted peptide MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells.

Chen M, Liu B, Gao Q, Zhuo Y, Ge J

Investigative ophthalmology & visual science1 Sept 2011Cited by 31 (Europe PMC)

PMID21697135 (opens in a new tab)DOI10.1167/iovs.11-7524 (opens in a new tab)PepBankPUB-21697135
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human trabecular meshwork cells, MTP-131 pretreatment prevented H2O2-induced mitochondrial depolarization compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 prevented the loss of mitochondrial electrical balance caused by hydrogen peroxide, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential after H2O2
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the H(2)O(2)-induced mitochondrial depolarization was prevented
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.
  2. 02LabIn vitro (cells)Mechanism

    In human trabecular meshwork cells, MTP-131 pretreatment decreased intracellular ROS compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 lowered harmful reactive oxygen molecules made after hydrogen peroxide stress, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseIntracellular ROS after H2O2
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    intracellular ROS, LDH release, and apoptosis were significantly decreased
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human trabecular meshwork cells, MTP-131 pretreatment decreased LDH release compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 reduced a marker of cell damage after hydrogen peroxide stress, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLDH release (cell damage) after H2O2
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Cell viability and death · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    intracellular ROS, LDH release, and apoptosis were significantly decreased
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.
  4. 04LabIn vitro (cells)Efficacy outcome

    In human trabecular meshwork cells, MTP-131 pretreatment decreased apoptosis compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 reduced programmed cell death after hydrogen peroxide stress, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseApoptosis after H2O2
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Cell viability and death · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    intracellular ROS, LDH release, and apoptosis were significantly decreased
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.
  5. 05LabIn vitro (cells)Mechanism

    In human trabecular meshwork cells, MTP-131 pretreatment inhibited H2O2-induced cytochrome c release from mitochondria to cytoplasm compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 blocked the leak of cytochrome c out of mitochondria after hydrogen peroxide stress, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCytochrome c release from mitochondria
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Cell viability and death · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    release of cytochrome c from mitochondria to cytoplasm and activation of caspase 3 were inhibited
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.
  6. 06LabIn vitro (cells)Mechanism

    In human trabecular meshwork cells, MTP-131 pretreatment inhibited H2O2-induced caspase 3 activation compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 blocked activation of the cell-death enzyme caspase 3 after hydrogen peroxide stress, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCaspase 3 activation
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Cell viability and death · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    release of cytochrome c from mitochondria to cytoplasm and activation of caspase 3 were inhibited
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.
  7. 07LabIn vitro (cells)Mechanism

    In human trabecular meshwork cells, MTP-131 alleviated H2O2-induced cytoskeleton changes compared with H2O2 alone.

    In plain wordsIn cells, MTP-131 reduced changes to the cell skeleton caused by hydrogen peroxide, compared with hydrogen peroxide alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCytoskeleton changes after H2O2
    Study

    humann: not reported in source

    Immortalized (iHTM) and glaucomatous (GTM(3)) human trabecular meshwork cells under H2O2 stress
    Comparator
    H2O2 alone
    Outcome group
    Cell viability and death · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, cytoskeleton changes caused by H(2)O(2) were also alleviated by MTP-131.
    1 context sentence
    Summary · context
    Cultured iHTM and GTM(3) cells were pretreated with MTP-131 for 1 hour, and sustained oxidative stress was induced by subjecting TM cells to 200 μM hydrogen peroxide (H(2)O(2)) for 24 hours.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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