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Study · In vitro (cells) · 2012

4 results

Mitochondria-targeted antioxidant attenuates high glucose-induced P38 MAPK pathway activation in human neuroblastoma cells.

Cao M, Jiang J, Du Y, Yan P

Molecular medicine reports9 Jan 2012Cited by 27 (Europe PMC)

PMID22245807 (opens in a new tab)PMCIDPMC3493100 (opens in a new tab)DOI10.3892/mmr.2012.746 (opens in a new tab)PepBankPUB-22245807
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In SH-SY5Y neuroblastoma cells, SS31 peptide suppressed the high glucose-induced increase in P38 phosphorylation.

    In plain wordsIn human nerve-type cells, SS31 peptide blocked the rise in P38 activation caused by high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseP38 MAPK phosphorylation
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells with high glucose
    Comparator
    High glucose without SS31
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results showed that high glucose promoted significantly increased P38 phosphorylation which was efficiently suppressed by the application of the SS31 peptide under the experimental conditions.
    1 context sentence
    Summary · context
    In this study, we employed a novel mitochondria-targeted antioxidant, SS31 peptide, on high glucose-insulted neuroblastoma cells (SH-SY5Y).
  2. 02LabIn vitro (cells)Mechanism

    In SH-SY5Y cells, SS31 peptide attenuated the high glucose-induced elevation of mitochondrial reactive oxygen species.

    In plain wordsIn human nerve-type cells, SS31 peptide reduced the rise in mitochondrial reactive oxygen species caused by high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial ROS elevation
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells with high glucose
    Comparator
    High glucose without SS31
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    associated with the impact of the SS31 peptide on attenuating high glucose-induced mitochondrial ROS (reactive oxygen species) elevation
    1 context sentence
    Summary · context
    In this study, we employed a novel mitochondria-targeted antioxidant, SS31 peptide, on high glucose-insulted neuroblastoma cells (SH-SY5Y).
  3. 03LabIn vitro (cells)Mechanism

    In SH-SY5Y cells, SS31 peptide attenuated the high glucose-induced collapse of mitochondrial membrane potential.

    In plain wordsIn human nerve-type cells, SS31 peptide reduced the loss of mitochondrial membrane potential caused by high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial membrane potential collapse
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells with high glucose
    Comparator
    High glucose without SS31
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    associated with the impact of the SS31 peptide on attenuating high glucose-induced mitochondrial ROS (reactive oxygen species) elevation and mitochondrial membrane potential collapse
    1 context sentence
    Summary · context
    In this study, we employed a novel mitochondria-targeted antioxidant, SS31 peptide, on high glucose-insulted neuroblastoma cells (SH-SY5Y).
  4. 04LabIn vitro (cells)Efficacy outcome

    In SH-SY5Y cells, SS31 peptide significantly attenuated high glucose-induced apoptosis.

    In plain wordsIn human nerve-type cells, SS31 peptide reduced the cell death caused by high glucose.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHigh glucose-induced apoptosis
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells with high glucose
    Comparator
    High glucose without SS31
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The addition of SS31 peptide significantly attenuated high-gluose-induced apoptosis.
    1 context sentence
    Summary · context
    In this study, we employed a novel mitochondria-targeted antioxidant, SS31 peptide, on high glucose-insulted neuroblastoma cells (SH-SY5Y).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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