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Study · In vitro (cells) · 2024

4 results

SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.

Ye P, Liu H, Qin Y, Li Z, Huang Z, Bu X, Peng Q, Duan N, Wang W, Wang X

Chemico-biological interactions26 Jul 2024Cited by 10 (Europe PMC)

PMID39069114 (opens in a new tab)DOI10.1016/j.cbi.2024.111166 (opens in a new tab)PepBankPUB-39069114
Publisher pagePubMedAsk about this study
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Summary

Smoking is a well-established risk factor for several oral diseases, including oral cancer, oral leukoplakia and periodontitis, primarily related to reactive oxygen species (ROS). SS-31, a mitochondria-targeting tetrapeptide, has exhibited demonstrable efficacy in medical conditions by attenuating mitochondrial ROS production. However, its potential in the treatment of oral diseases remains underexplored. The aim of this study was to investigate the therapeutic potential of SS-31 in mitigating smoking-induced oral epithelial injury. Through in vitro experiments, our results indicate that SS-31 plays a protective role against cigarette smoke extract (CSE) by reducing oxidative stress, attenuating inflammatory response, and restoring mitochondrial function. Furthermore, we found that mitophagy, regulated by PINK1 (PTEN-induced putative kinase 1)/Parkin (Parkin RBR E3 ubiquitin-protein ligase), was critical for the protective role of SS-31. Our findings offer valuable insights into SS-31's therapeutic potential in mitigating CSE-induced oxidative stress, inflammatory response, and mitochondrial dysfunction in oral epithelial cells. This study provides novel intervention targets for smoking-related oral diseases.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In oral epithelial cells exposed to cigarette smoke extract, SS‑31 reduced oxidative stress.

    In plain wordsIn cells, SS‑31 lowered oxidative stress caused by cigarette smoke extract.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative stress
    Study

    n: not reported in source

    Oral epithelial cells exposed to cigarette smoke extract
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Through in vitro experiments, our results indicate that SS-31 plays a protective role against cigarette smoke extract (CSE) by reducing oxidative stress, attenuating inflammatory response, and restoring mitochondrial function.
    1 context sentence
    Title · context
    SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
  2. 02LabIn vitro (cells)Efficacy outcome

    In oral epithelial cells exposed to cigarette smoke extract, SS‑31 attenuated the inflammatory response.

    In plain wordsIn cells, SS‑31 weakened the inflammatory response to cigarette smoke extract.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInflammatory response
    Study

    n: not reported in source

    Oral epithelial cells exposed to cigarette smoke extract
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Through in vitro experiments, our results indicate that SS-31 plays a protective role against cigarette smoke extract (CSE) by reducing oxidative stress, attenuating inflammatory response, and restoring mitochondrial function.
    1 context sentence
    Title · context
    SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
  3. 03LabIn vitro (cells)Efficacy outcome

    In oral epithelial cells exposed to cigarette smoke extract, SS‑31 restored mitochondrial function.

    In plain wordsIn cells, SS‑31 restored mitochondrial function damaged by cigarette smoke extract.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial function
    Study

    n: not reported in source

    Oral epithelial cells exposed to cigarette smoke extract
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Through in vitro experiments, our results indicate that SS-31 plays a protective role against cigarette smoke extract (CSE) by reducing oxidative stress, attenuating inflammatory response, and restoring mitochondrial function.
    1 context sentence
    Title · context
    SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
  4. 04LabIn vitro (cells)Mechanism

    In oral epithelial cells, PINK1/Parkin-regulated mitophagy was critical for the protective role of SS‑31.

    In plain wordsIn cells, a mitochondria clean-up pathway was needed for SS‑31 to protect against smoke extract.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableRole of PINK1/Parkin mitophagy in SS-31 protection
    Study

    n: not reported in source

    Oral epithelial cells exposed to cigarette smoke extract
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that mitophagy, regulated by PINK1 (PTEN-induced putative kinase 1)/Parkin (Parkin RBR E3 ubiquitin-protein ligase), was critical for the protective role of SS-31.
    1 context sentence
    Title · context
    SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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