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Study · In vitro (cells) · 2023

1 result

Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).

Zhang H, Ran M, Jiang L, Sun X, Qiu T, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G

Ecotoxicology and environmental safety17 Nov 2023Cited by 25 (Europe PMC)

PMID37979351 (opens in a new tab)DOI10.1016/j.ecoenv.2023.115711 (opens in a new tab)PepBankPUB-37979351
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cells exposed to DEHP, SS‑31 pre-treatment, which improved mitochondrial function, decreased the expression of the PERK pathway.

    In plain wordsIn cells, SS‑31 improved mitochondrial function and lowered activity of the PERK stress pathway.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePERK pathway expression after SS-31
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, the improvement of mitochondrial dysfunction decreased the expression of PERK pathway by using SS-31(a protective agent for mitochondrial function).
    1 context sentence
    Summary · context
    This view has also been confirmed in TM3 and TM4 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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