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Study · In vitro (cells) · 2024

4 results

SS-31 modification alleviates ferroptosis induced by superparamagnetic iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes.

Lu Q, Yao X, Zheng H, Ou J, You J, Zhang Q, Guo W, Xu J, Geng L, Liu Q, Pei N, Gong Y, Zhu H, Shen Y

Heliyon27 Sept 2024Cited by 8 (Europe PMC)

PMID39506934 (opens in a new tab)PMCIDPMC11538732 (opens in a new tab)DOI10.1016/j.heliyon.2024.e38584 (opens in a new tab)PepBankPUB-39506934
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In hypoxia/reoxygenation H9C2 cells, SPION@SS‑31 reduced SPION-induced cell damage.

    In plain wordsIn heart cells, SS‑31 loaded onto iron oxide particles reduced the cell damage the particles caused.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSPION-induced cell damage
    Study

    n: not reported in source

    Hypoxia/reoxygenation H9C2 cardiomyocytes treated with SPION
    Comparator
    SPION alone
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SPION@SS-31 produced results comparable to the H/R group, implying that SS-31 can notably reduce cell damage induced by SPION.
    1 context sentence
    Summary · context
    To study the dose- and time-dependent cytotoxic effects and assess the influence of SS-31 on reducing SPION-induced damage, hypoxia/reoxygenation(H/R) H9C2 cells were treated with either SPION or SPION@SS-31.
  2. 02LabIn vitro (cells)Mechanism

    In hypoxia/reoxygenation H9C2 cells, SS‑31 decreased SPION-induced mitochondrial MDA production.

    In plain wordsIn heart cells, SS‑31 lowered a marker of fat damage in mitochondria caused by iron oxide particles.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial MDA production
    Study

    n: not reported in source

    Hypoxia/reoxygenation H9C2 cardiomyocytes treated with SPION
    Comparator
    SPION alone
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, SS-31 significantly alleviated SPION-induced ferroptosis by decreasing mitochondrial MDA production
    1 context sentence
    Summary · context
    To study the dose- and time-dependent cytotoxic effects and assess the influence of SS-31 on reducing SPION-induced damage, hypoxia/reoxygenation(H/R) H9C2 cells were treated with either SPION or SPION@SS-31.
  3. 03LabIn vitro (cells)Mechanism

    In hypoxia/reoxygenation H9C2 cells, SS‑31 maintained GSH and GPX4 levels in the presence of SPION.

    In plain wordsIn heart cells, SS‑31 kept levels of two protective molecules higher than with iron oxide particles alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseGSH and GPX4 levels
    Study

    n: not reported in source

    Hypoxia/reoxygenation H9C2 cardiomyocytes treated with SPION
    Comparator
    SPION alone
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    maintaining GSH and GPX4 levels
    1 context sentence
    Summary · context
    To study the dose- and time-dependent cytotoxic effects and assess the influence of SS-31 on reducing SPION-induced damage, hypoxia/reoxygenation(H/R) H9C2 cells were treated with either SPION or SPION@SS-31.
  4. 04LabIn vitro (cells)Efficacy outcome

    In hypoxia/reoxygenation H9C2 cells, SS‑31 alleviated SPION-induced ferroptosis.

    In plain wordsIn heart cells, SS‑31 reduced a type of cell death caused by iron oxide particles.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSPION-induced ferroptosis
    Study

    n: not reported in source

    Hypoxia/reoxygenation H9C2 cardiomyocytes treated with SPION
    Comparator
    SPION alone
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, SS-31 significantly alleviated SPION-induced ferroptosis by decreasing mitochondrial MDA production and maintaining GSH and GPX4 levels, indicating its possibility to reverse SPION-induced cytotoxicity.
    1 context sentence
    Summary · context
    To study the dose- and time-dependent cytotoxic effects and assess the influence of SS-31 on reducing SPION-induced damage, hypoxia/reoxygenation(H/R) H9C2 cells were treated with either SPION or SPION@SS-31.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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