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Study · In vitro (cells) · mouse · 2019

4 results

SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia.

Mo Y, Deng S, Zhang L, Huang Y, Li W, Peng Q, Liu Z, Ai Y

Biochemical and biophysical research communications1 Oct 2019Cited by 28 (Europe PMC)

PMID31582222 (opens in a new tab)DOI10.1016/j.bbrc.2019.09.077 (opens in a new tab)PepBankPUB-31582222
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In LPS-stimulated BV-2 microglial cells, SS‑31 preserved mitochondrial ultrastructure against LPS-induced damage.

    In plain wordsIn mouse microglial cells exposed to a bacterial toxin, SS‑31 kept the inner structure of mitochondria from being damaged.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLPS-induced mitochondrial ultrastructure damage
    Study

    mousen: not reported in source

    BV-2 murine microglial cells stimulated with lipopolysaccharide
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The morphological study showed that SS-31 preserved LPS-induced mitochondrial ultrastructure by reducing the fission protein 1 (Fis1) expression.
    1 context sentence
    Summary · context
    In this study, we investigated that SS-31 protected the murine cultured microglial cells (BV-2) against lipopolysaccharide (LPS)-induced inflammation and oxidative stress through stabilizing mitochondrial morphology.
  2. 02LabIn vitro (cells)Mechanism

    In LPS-stimulated BV-2 microglial cells, SS‑31 reduced the expression of the mitochondrial fission protein 1 (Fis1).

    In plain wordsIn mouse microglial cells exposed to a bacterial toxin, SS‑31 lowered the level of the mitochondrial fission protein Fis1.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseFis1 expression
    Study

    mousen: not reported in source

    BV-2 murine microglial cells stimulated with lipopolysaccharide
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The morphological study showed that SS-31 preserved LPS-induced mitochondrial ultrastructure by reducing the fission protein 1 (Fis1) expression.
    1 context sentence
    Summary · context
    In this study, we investigated that SS-31 protected the murine cultured microglial cells (BV-2) against lipopolysaccharide (LPS)-induced inflammation and oxidative stress through stabilizing mitochondrial morphology.
  3. 03LabIn vitro (cells)Efficacy outcome

    In LPS-stimulated BV-2 microglial cells, SS‑31 protected against inflammation, and the effect was linked to suppression of Fis1.

    In plain wordsIn mouse microglial cells exposed to a bacterial toxin, SS‑31 reduced inflammation, linked to lower Fis1.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLPS-induced inflammation
    Study

    mousen: not reported in source

    BV-2 murine microglial cells stimulated with lipopolysaccharide
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometry and Western blot verified that SS-31 defended the BV-2 cells against LPS-stimulated inflammation and oxidative stress via suppressing Fis1.
    1 context sentence
    Summary · context
    In this study, we investigated that SS-31 protected the murine cultured microglial cells (BV-2) against lipopolysaccharide (LPS)-induced inflammation and oxidative stress through stabilizing mitochondrial morphology.
  4. 04LabIn vitro (cells)Efficacy outcome

    In LPS-stimulated BV-2 microglial cells, SS‑31 protected against oxidative stress, and the effect was linked to suppression of Fis1.

    In plain wordsIn mouse microglial cells exposed to a bacterial toxin, SS‑31 reduced oxidative stress, linked to lower Fis1.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseLPS-induced oxidative stress
    Study

    mousen: not reported in source

    BV-2 murine microglial cells stimulated with lipopolysaccharide
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometry and Western blot verified that SS-31 defended the BV-2 cells against LPS-stimulated inflammation and oxidative stress via suppressing Fis1.
    1 context sentence
    Summary · context
    In this study, we investigated that SS-31 protected the murine cultured microglial cells (BV-2) against lipopolysaccharide (LPS)-induced inflammation and oxidative stress through stabilizing mitochondrial morphology.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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