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Study · In vitro (cells) · 2015

5 results

Mitochondria-Targeted Antioxidant Peptide SS31 Protects Cultured Human Lens Epithelial Cells against Oxidative Stress.

Cai M, Li J, Lin S, Chen X, Huang J, Jiang X, Yang L, Luo Y

Current eye research13 Oct 2014Cited by 25 (Europe PMC)

PMID25310141 (opens in a new tab)DOI10.3109/02713683.2014.959607 (opens in a new tab)PepBankPUB-25310141
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured human lens epithelial cells, SS31 protected against t-BHP-induced apoptosis.

    In plain wordsIn lab-grown human lens cells, SS31 protected the cells from oxidative-stress-induced cell death.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Decreaset-BHP-induced apoptosis
    Study

    humann: not reported in source

    HLEB-3 human lens epithelial cells with t-BHP oxidative stress
    Outcome group
    Cell viability and death · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31 protected HLEB-3 cells against t-BHP-induced cell apoptosis
    2 context sentences
    Summary · context
    To investigate the effects of the mitochondria-targeted peptide, SS31, on cultured human lens epithelial cells (HLECs) under conditions of oxidative stress.
    Summary · context
    HLEB-3 cells were first treated with SS31 for 2 h and then with 500 µM t-BHP for 6 h.
  2. 02LabIn vitro (cells)Mechanism

    In cultured human lens epithelial cells under t-BHP stress, SS31 reduced mitochondrial ROS.

    In plain wordsIn lab-grown human lens cells, SS31 lowered reactive oxygen species made under oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseReactive oxygen species (ROS)
    Study

    humann: not reported in source

    HLEB-3 human lens epithelial cells with t-BHP oxidative stress
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced ROS, maintained ΔΨms, and inhibited activation of JNK and p38 pathways.
    3 context sentences
    Summary · context
    Reactive oxygen species (ROS) were measured by MitoSOX staining.
    Summary · context
    To investigate the effects of the mitochondria-targeted peptide, SS31, on cultured human lens epithelial cells (HLECs) under conditions of oxidative stress.
    Summary · context
    HLEB-3 cells were first treated with SS31 for 2 h and then with 500 µM t-BHP for 6 h.
  3. 03LabIn vitro (cells)Mechanism

    In cultured human lens epithelial cells under t-BHP stress, SS31 maintained mitochondrial membrane potential.

    In plain wordsIn lab-grown human lens cells, SS31 helped keep the mitochondrial membrane potential steady under oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential (ΔΨm)
    Study

    humann: not reported in source

    HLEB-3 human lens epithelial cells with t-BHP oxidative stress
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    maintained ΔΨms, and inhibited activation of JNK and p38 pathways.
    3 context sentences
    Summary · context
    Changes in mitochondrial membrane potential (ΔΨm) were detected using the JC-1 fluorescent dye.
    Summary · context
    To investigate the effects of the mitochondria-targeted peptide, SS31, on cultured human lens epithelial cells (HLECs) under conditions of oxidative stress.
    Summary · context
    HLEB-3 cells were first treated with SS31 for 2 h and then with 500 µM t-BHP for 6 h.
  4. 04LabIn vitro (cells)Mechanism

    In cultured human lens epithelial cells under t-BHP stress, SS31 inhibited activation of the JNK pathway.

    In plain wordsIn lab-grown human lens cells, SS31 blocked activation of the stress signal JNK.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseJNK activation
    Study

    humann: not reported in source

    HLEB-3 human lens epithelial cells with t-BHP oxidative stress
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited activation of JNK and p38 pathways.
    3 context sentences
    Summary · context
    Activation of p38 and c-Jun N-terminal kinases (JNKs) were quantified by Western Blot analysis.
    Summary · context
    To investigate the effects of the mitochondria-targeted peptide, SS31, on cultured human lens epithelial cells (HLECs) under conditions of oxidative stress.
    Summary · context
    HLEB-3 cells were first treated with SS31 for 2 h and then with 500 µM t-BHP for 6 h.
  5. 05LabIn vitro (cells)Mechanism

    In cultured human lens epithelial cells under t-BHP stress, SS31 inhibited activation of the p38 pathway.

    In plain wordsIn lab-grown human lens cells, SS31 blocked activation of the stress signal p38.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Decreasep38 activation
    Study

    humann: not reported in source

    HLEB-3 human lens epithelial cells with t-BHP oxidative stress
    Outcome group
    Receptor activity and mechanism · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited activation of JNK and p38 pathways.
    3 context sentences
    Summary · context
    Activation of p38 and c-Jun N-terminal kinases (JNKs) were quantified by Western Blot analysis.
    Summary · context
    To investigate the effects of the mitochondria-targeted peptide, SS31, on cultured human lens epithelial cells (HLECs) under conditions of oxidative stress.
    Summary · context
    HLEB-3 cells were first treated with SS31 for 2 h and then with 500 µM t-BHP for 6 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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