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Study · In vitro (cells) · 2025

10 results

Milk-derived exosome-loaded SS31 as a novel strategy to mitigate UV-induced photodamage in skin.

Luo D, Mao Y, Zhang S, Shen S, Ge X, Zhang L

Journal of photochemistry and photobiology. B, Biology13 Feb 2025Cited by 7 (Europe PMC)

PMID39970726 (opens in a new tab)DOI10.1016/j.jphotobiol.2025.113125 (opens in a new tab)PepBankPUB-39970726
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human dermal fibroblasts, Exo-SS31 reduced damage induced by ultraviolet exposure.

    In plain wordsIn cells, SS31 loaded in milk exosomes reduced skin cell damage from UV light.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseUV-induced damage in human dermal fibroblasts
    Study

    humann: not reported in source

    Human dermal fibroblasts (HDF)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exo-SS31 is an effective antioxidant capable of mitigating Human dermal fibroblast (HDF) damage induced by ultraviolet exposure
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  2. 02LabIn vitro (cells)Mechanism

    In human dermal fibroblasts, Exo-SS31 suppressed ROS production after ultraviolet exposure.

    In plain wordsIn cells, SS31 loaded in milk exosomes lowered harmful reactive oxygen molecules after UV light.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseROS production after UV exposure
    Study

    humann: not reported in source

    Human dermal fibroblasts (HDF)
    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    suppressing ROS production, and achieving greater therapeutic efficacy than SS31 alone.
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human dermal fibroblasts, Exo-SS31 had greater therapeutic efficacy than SS31 alone against UV damage.

    In plain wordsIn cells, SS31 loaded in milk exosomes worked better than SS31 alone against UV damage.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseEfficacy of Exo-SS31 versus SS31 alone
    Study

    humann: not reported in source

    Human dermal fibroblasts (HDF)
    Comparator
    SS31 alone
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    achieving greater therapeutic efficacy than SS31 alone.
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  4. 04LabIn vitro (cells)Mechanism

    Exo-SS31 regulated superoxide dismutase levels within the skin; the abstract gives no direction.

    In plain wordsSS31 loaded in milk exosomes changed levels of an antioxidant enzyme in skin; the direction is not stated.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedSuperoxide dismutase (SOD) level
    Study

    n: not reported in source

    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This complex can regulate the levels of superoxide dismutase (SOD) and glutathione (GSH) within the skin
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  5. 05LabIn vitro (cells)Mechanism

    Exo-SS31 regulated glutathione levels within the skin; the abstract gives no direction.

    In plain wordsSS31 loaded in milk exosomes changed levels of an antioxidant molecule in skin; the direction is not stated.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Direction not reportedGlutathione (GSH) level
    Study

    n: not reported in source

    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This complex can regulate the levels of superoxide dismutase (SOD) and glutathione (GSH) within the skin
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  6. 06LabIn vitro (cells)Mechanism

    Exo-SS31 inhibited the expression of pMAPK pathway proteins triggered by UV radiation.

    In plain wordsSS31 loaded in milk exosomes lowered UV-triggered stress-pathway proteins. The abstract does not name the model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseUV-triggered pMAPK pathway protein expression
    Study

    n: not reported in source

    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibit the expression of proteins in pathways such as pMAPK and AP-1 triggered by UV radiation
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  7. 07LabIn vitro (cells)Mechanism

    Exo-SS31 inhibited the expression of AP-1 pathway proteins triggered by UV radiation.

    In plain wordsSS31 loaded in milk exosomes lowered UV-triggered AP-1 pathway proteins. The abstract does not name the model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseUV-triggered AP-1 pathway protein expression
    Study

    n: not reported in source

    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibit the expression of proteins in pathways such as pMAPK and AP-1 triggered by UV radiation
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  8. 08LabIn vitro (cells)Mechanism

    Exo-SS31 reduced the expression of matrix metalloproteinase MMP1.

    In plain wordsSS31 loaded in milk exosomes lowered a collagen-degrading enzyme, MMP1. The abstract does not name the model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMMP1 expression
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduce the expression of the matrix metalloproteinases MMP1 and MMP3.
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  9. 09LabIn vitro (cells)Mechanism

    Exo-SS31 reduced the expression of matrix metalloproteinase MMP3.

    In plain wordsSS31 loaded in milk exosomes lowered a collagen-degrading enzyme, MMP3. The abstract does not name the model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMMP3 expression
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduce the expression of the matrix metalloproteinases MMP1 and MMP3.
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.
  10. 10LabIn vitro (cells)Efficacy outcome

    Exo-SS31 prevented collagen degradation in the dermis.

    In plain wordsSS31 loaded in milk exosomes reduced collagen breakdown after UV exposure. The abstract does not name the model.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDermal collagen degradation
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exo-SS31 effectively prevents collagen degradation in the dermis
    1 context sentence
    Summary · context
    In this study, we developed a novel antioxidant complex, Exo-SS31, by loading the antioxidant peptide SS31 (also known as MTP-131, elamipretide) into milk-derived exosomes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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