SS-31 protect retinal pigment epithelial cells from H₂ O₂ -induced cell injury by reducing apoptosis.

Bai J, Yang Y, Wu D, Yang F

Clinical and experimental pharmacology & physiology28 Mar 2021Cited by 16 (Europe PMC)

PMID33774859PMCIDPMC8252508DOI10.1111/1440-1681.13484PepBankPUB-33774859

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In ARPE-19 retinal pigment epithelial cells, SS‑31 attenuated the H2O2-induced loss of cell viability.
In plain wordsIn lab retinal cells, SS‑31 reduced the loss of cell viability caused by hydrogen peroxide.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseCell viability
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
we found that SS-31 attenuated hydrogen peroxide (H₂ O₂ )-induced loss of cell viability
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485901
02LabIn vitro (cells)Mechanism
In ARPE-19 retinal pigment epithelial cells, SS‑31 reduced H2O2-induced oxidative damage.
In plain wordsIn lab retinal cells, SS‑31 reduced oxidative damage caused by hydrogen peroxide.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseOxidative damage
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
we found that SS-31 attenuated hydrogen peroxide (H₂ O₂ )-induced loss of cell viability, reduced oxidative damage and cell apoptosis in RPE cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485902
03LabIn vitro (cells)Mechanism
In ARPE-19 retinal pigment epithelial cells, SS‑31 reduced H2O2-induced apoptosis.
In plain wordsIn lab retinal cells, SS‑31 reduced cell death (apoptosis) caused by hydrogen peroxide.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseCell apoptosis
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
we found that SS-31 attenuated hydrogen peroxide (H₂ O₂ )-induced loss of cell viability, reduced oxidative damage and cell apoptosis in RPE cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485903
04LabIn vitro (cells)Mechanism
In ARPE-19 cells, HO-1 expression increased significantly with SS‑31 pretreatment compared with the H2O2 group.
In plain wordsIn lab retinal cells, SS‑31 pretreatment raised the antioxidant protein HO-1 compared with hydrogen peroxide alone.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseHO-1 expression
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Comparator
H2O2 group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
HO-1, Trx-1 and Nrf-2 expression levels significantly increased on pre-treatment with SS-31 compared with the H₂ O₂ group.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485904
05LabIn vitro (cells)Mechanism
In ARPE-19 cells, Trx-1 expression increased significantly with SS‑31 pretreatment compared with the H2O2 group.
In plain wordsIn lab retinal cells, SS‑31 pretreatment raised the antioxidant protein Trx-1 compared with hydrogen peroxide alone.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseTrx-1 expression
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Comparator
H2O2 group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
HO-1, Trx-1 and Nrf-2 expression levels significantly increased on pre-treatment with SS-31 compared with the H₂ O₂ group.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485905
06LabIn vitro (cells)Mechanism
In ARPE-19 cells, Nrf-2 expression increased significantly with SS‑31 pretreatment compared with the H2O2 group.
In plain wordsIn lab retinal cells, SS‑31 pretreatment raised the antioxidant regulator Nrf-2 compared with hydrogen peroxide alone.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseNrf-2 expression
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Comparator
H2O2 group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
HO-1, Trx-1 and Nrf-2 expression levels significantly increased on pre-treatment with SS-31 compared with the H₂ O₂ group.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485906
07LabIn vitro (cells)Mechanism
In ARPE-19 cells, SS‑31 downregulated Bax.
In plain wordsIn lab retinal cells, SS‑31 lowered the cell death protein Bax.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseBax expression
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
SS-31 inhibited apoptosis through the downregulation of Bax and the upregulation of Bcl-2.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485907
08LabIn vitro (cells)Mechanism
In ARPE-19 cells, SS‑31 upregulated Bcl-2.
In plain wordsIn lab retinal cells, SS‑31 raised the cell survival protein Bcl-2.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseBcl-2 expression
Study
n: not reported in source
ARPE-19 retinal pigment epithelial cells with H2O2 injury
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
SS-31 inhibited apoptosis through the downregulation of Bax and the upregulation of Bcl-2.
1 context sentence(design, population, supporting numbers)
Summary · context
Evidence has shown that effects from oxidative stress induced damage of retinal or human retinal pigment epithelial (RPE) cells.
Report a problemFND-3377485908

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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