Protective Effect of Mitochondrially Targeted Peptide Against Oxidant Injury of Cone Photoreceptors Through Preventing Necroptosis Pathway.

He Y, Xu Y, Chen Z, He B, Quan Z, Zhang R, Ren Y

Journal of biomedical nanotechnology1 Feb 2021Cited by 4 (Europe PMC)

PMID33785098DOI10.1166/jbn.2021.3017PepBankPUB-33785098

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In 661W cells, the malondialdehyde level in the SS31 group was lower than in the hydrogen peroxide group.
In plain wordsIn lab cells, SS31 lowered a marker of oxidative damage (MDA) compared with hydrogen peroxide alone.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMDA level (SS31 group)
Study
n: not reported in source
661W cells with hydrogen peroxide-induced oxidative injury
Comparator
hydrogen peroxide group
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
The level of MDA in the SS31 group, Nec-1 group and combined treatment of SS31 +NEC1 group decreased significantly compared with the H₂O₂ group.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, oxidative damage cell model was established and divided into a control group, H₂O₂ group, SS31 +NEC1 group, SS31 +H₂O₂ group, and SS31 +NEC1 +H₂O₂ group, for different interventions.
Report a problemFND-3378509802
02LabIn vitro (cells)Mechanism
In 661W cells, the hydrogen peroxide-induced rise in RIP3 was downregulated in the SS31 treatment group.
In plain wordsIn lab cells, SS31 reduced the hydrogen peroxide-induced rise of RIP3, a cell death marker.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseRIP3 level (necroptosis marker)
Study
n: not reported in source
661W cells with hydrogen peroxide-induced oxidative injury
Comparator
hydrogen peroxide group
Outcome group
Cell viability and death · Eye
Studied dose
Dose not stated
Source sentences
Summary
The level of RIP3 in the H₂O₂ group was significantly increased, while this level was downregulated in the SS31 and NEC1 treatment groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, oxidative damage cell model was established and divided into a control group, H₂O₂ group, SS31 +NEC1 group, SS31 +H₂O₂ group, and SS31 +NEC1 +H₂O₂ group, for different interventions.
Report a problemFND-3378509804

Studies that did not test the peptide alone2

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

03LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In 661W cells with hydrogen peroxide injury, combined treatment with Nec1 reduced reactive oxygen species production versus the hydrogen peroxide group; the combination does not isolate SS31.
In plain wordsIn lab cells, a combined treatment including Nec1 lowered reactive oxygen species compared with hydrogen peroxide alone.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseROS production with Nec1 combined treatment
Study
n: not reported in source
661W cells with hydrogen peroxide-induced oxidative injury
Comparator
hydrogen peroxide group
Outcome group
Oxidative stress · Eye
Source sentences
Summary
Nec1 combined treatment significantly reduced reactive oxygen species (ROS) production compared with that in the H₂O₂ group.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, oxidative damage cell model was established and divided into a control group, H₂O₂ group, SS31 +NEC1 group, SS31 +H₂O₂ group, and SS31 +NEC1 +H₂O₂ group, for different interventions.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3378509801
04LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In 661W cells, the malondialdehyde level with combined SS31 plus NEC1 treatment was lower than in the hydrogen peroxide group.
In plain wordsIn lab cells, SS31 plus NEC1 together lowered an oxidative damage marker (MDA) compared with hydrogen peroxide alone.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMDA level (SS31 plus NEC1 combined treatment)
Study
n: not reported in source
661W cells with hydrogen peroxide-induced oxidative injury
Comparator
hydrogen peroxide group
Outcome group
Oxidative stress · Eye
Source sentences
Summary
The level of MDA in the SS31 group, Nec-1 group and combined treatment of SS31 +NEC1 group decreased significantly compared with the H₂O₂ group.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, oxidative damage cell model was established and divided into a control group, H₂O₂ group, SS31 +NEC1 group, SS31 +H₂O₂ group, and SS31 +NEC1 +H₂O₂ group, for different interventions.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3378509803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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