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Study · In vitro (cells) · 2015

9 results

Protective effects of SS31 on t‑BHP induced oxidative damage in 661W cells.

Ma W, Zhu X, Ding X, Li T, Hu Y, Hu X, Yuan L, Lei L, Hu A, Luo Y, Tang S

Molecular medicine reports7 Jul 2015Cited by 17 (Europe PMC)

PMID26165373 (opens in a new tab)PMCIDPMC4581771 (opens in a new tab)DOI10.3892/mmr.2015.4055 (opens in a new tab)PepBankPUB-26165373
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In 661W cells, viability improved with SS31 between 100 nM and 1 µM compared with untreated controls.

    In plain wordsIn lab-grown eye cells, SS31 between 100 nM and 1 µM improved cell survival compared with untreated cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCell viability
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    Untreated control
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 nM to 1 µMAs given in this study.

    Source sentences

    Summary
    The viability of the cells improved following treatment with SS31 between 100 nM and 1 µM, compared with untreated control group.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  2. 02LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 at 10 nM reduced annexin V-positive cells to 13.6% from 20.0% with t-BHP alone.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 at 10 nM reduced dying cells compared with stress alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAnnexin V-positive (apoptotic) cells
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP treatment group
    Outcome group
    Neuroprotection · Eye
    Studied dose
    10 nMAs given in this study.

    Measurements

    Annexin V-positive cells
    13.6%
    SS-31 10 nM

    Source sentences

    Summary
    Compared with the t‑BHP treatment group (20.0±3.8%), the number of annexin V‑positive cells decreased dose‑dependently to 13.6±2.6, 9.8±0.5 and 7.4±2.0% in the SS‑31 treated group at concentrations of 10 nM, 100 nM and 1 µM, respectively.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  3. 03LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 at 100 nM reduced annexin V-positive cells to 9.8% from 20.0% with t-BHP alone.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 at 100 nM reduced dying cells compared with stress alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAnnexin V-positive (apoptotic) cells
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP treatment group
    Outcome group
    Neuroprotection · Eye
    Studied dose
    100 nMAs given in this study.

    Measurements

    Annexin V-positive cells
    9.8%
    SS-31 100 nM

    Source sentences

    Summary
    Compared with the t‑BHP treatment group (20.0±3.8%), the number of annexin V‑positive cells decreased dose‑dependently to 13.6±2.6, 9.8±0.5 and 7.4±2.0% in the SS‑31 treated group at concentrations of 10 nM, 100 nM and 1 µM, respectively.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  4. 04LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 at 1 µM reduced annexin V-positive cells to 7.4% from 20.0% with t-BHP alone.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 at 1 µM reduced dying cells compared with stress alone.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseAnnexin V-positive (apoptotic) cells
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP treatment group
    Outcome group
    Neuroprotection · Eye
    Studied dose
    1 µMAs given in this study.

    Measurements

    Annexin V-positive cells
    7.4%
    SS-31 1 µM

    Source sentences

    Summary
    Compared with the t‑BHP treatment group (20.0±3.8%), the number of annexin V‑positive cells decreased dose‑dependently to 13.6±2.6, 9.8±0.5 and 7.4±2.0% in the SS‑31 treated group at concentrations of 10 nM, 100 nM and 1 µM, respectively.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  5. 05LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 significantly prevented the t-BHP-induced expression of nitrotyrosine.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 prevented a rise in a marker of oxidative damage to proteins.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNitrotyrosine expression
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS‑31 significantly prevented the t‑BHP‑induced expression of nitrotyrosine and 8‑OHdG, decreased the quantity of mitochondrial ROS, increased mitochondrial potential, and prevented the release of cytochrome c from mitochondria into the cytoplasm.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  6. 06LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 significantly prevented the t-BHP-induced expression of 8-OHdG.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 prevented a rise in a marker of oxidative damage to DNA.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Decrease8-OHdG expression
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS‑31 significantly prevented the t‑BHP‑induced expression of nitrotyrosine and 8‑OHdG, decreased the quantity of mitochondrial ROS, increased mitochondrial potential, and prevented the release of cytochrome c from mitochondria into the cytoplasm.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  7. 07LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 decreased the quantity of mitochondrial reactive oxygen species.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 lowered harmful oxygen molecules made by mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial ROS
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS‑31 significantly prevented the t‑BHP‑induced expression of nitrotyrosine and 8‑OHdG, decreased the quantity of mitochondrial ROS, increased mitochondrial potential, and prevented the release of cytochrome c from mitochondria into the cytoplasm.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  8. 08LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 increased mitochondrial membrane potential.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 raised the electrical charge that mitochondria need to work.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS‑31 significantly prevented the t‑BHP‑induced expression of nitrotyrosine and 8‑OHdG, decreased the quantity of mitochondrial ROS, increased mitochondrial potential, and prevented the release of cytochrome c from mitochondria into the cytoplasm.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.
  9. 09LabIn vitro (cells)Mechanism

    In t-BHP-stressed 661W cells, SS‑31 prevented the release of cytochrome c from mitochondria into the cytoplasm.

    In plain wordsIn lab-grown eye cells under stress, SS‑31 stopped a cell-death signal leaking out of mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseCytochrome c release from mitochondria
    Study

    n: not reported in source

    661W cell line with t-BHP oxidative stress
    Comparator
    t-BHP alone
    Outcome group
    Mitochondrial function · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with SS‑31 significantly prevented the t‑BHP‑induced expression of nitrotyrosine and 8‑OHdG, decreased the quantity of mitochondrial ROS, increased mitochondrial potential, and prevented the release of cytochrome c from mitochondria into the cytoplasm.
    1 context sentence
    Summary · context
    The present study aimed to investigate the ability of SS31, a novel mitochondria‑targeted peptide to protect against t‑BHP‑induced mitochondrial dysfunction and apoptosis in 661W cell lines.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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