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Study · In vitro (cells) · 2025

5 results

Mitochondria-Targeted SS31-Conjugated Liposome Attenuates Oxidative Stress in Endothelial and Skeletal Muscle Cells.

Kim EM, Han YH, Oh PS, Qi W, Lim ST, Jeong HJ

Journal of vascular research17 Jul 2025Cited by 1 (Europe PMC)

PMID40675137 (opens in a new tab)DOI10.1159/000547281 (opens in a new tab)PepBankPUB-40675137
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In HUVEC and C2C12 cells, the SS31-conjugated liposome (SS31-LP) showed pronounced mitochondrial localization.

    In plain wordsIn lab tests on cells, the SS31 liposome clearly reached the mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    Not applicableMitochondrial localization of SS31-LP
    Study

    n: not reported in source

    HUVEC and C2C12 cells
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SS31-LP demonstrated pronounced mitochondrial localization
    1 context sentence
    Summary · context
    The in vitro mitochondrial localization, cytotoxicity, antioxidant potential, and anti-apoptotic efficacy of SS31-LP were evaluated in HUVECs and C2C12 cells.
  2. 02LabIn vitro (cells)Other

    In HUVEC and C2C12 cells, SS31-LP internalization varied with the zeta potential of the formulation.

    In plain wordsIn lab tests on cells, how much SS31 liposome entered the cells depended on its surface charge.

    Peptide
    Elamipretide (SS-31)
    Outcome
    MixedCellular internalization of SS31-LP by zeta potential
    Study

    n: not reported in source

    HUVEC and C2C12 cells
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    showed variable cellular internalization based on zeta potential.
    1 context sentence
    Summary · context
    The in vitro mitochondrial localization, cytotoxicity, antioxidant potential, and anti-apoptotic efficacy of SS31-LP were evaluated in HUVECs and C2C12 cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In HUVEC and C2C12 cells, pretreatment with SS31-LP enhanced viability under oxidative stress caused by H2O2 or blue LEDs.

    In plain wordsIn lab tests on cells, pretreatment with the SS31 liposome kept more cells alive under oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCell viability under oxidative stress
    Study

    n: not reported in source

    HUVEC and C2C12 cells
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with SS31-LP enhanced cellular viability, mitigated oxidative damage, and reduced apoptosis in response to oxidative stress caused by H2O2 or blue LEDs.
    1 context sentence
    Summary · context
    The in vitro mitochondrial localization, cytotoxicity, antioxidant potential, and anti-apoptotic efficacy of SS31-LP were evaluated in HUVECs and C2C12 cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In HUVEC and C2C12 cells, pretreatment with SS31-LP mitigated oxidative damage caused by H2O2 or blue LEDs.

    In plain wordsIn lab tests on cells, pretreatment with the SS31 liposome reduced damage from oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseOxidative damage
    Study

    n: not reported in source

    HUVEC and C2C12 cells
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with SS31-LP enhanced cellular viability, mitigated oxidative damage, and reduced apoptosis in response to oxidative stress caused by H2O2 or blue LEDs.
    1 context sentence
    Summary · context
    The in vitro mitochondrial localization, cytotoxicity, antioxidant potential, and anti-apoptotic efficacy of SS31-LP were evaluated in HUVECs and C2C12 cells.
  5. 05LabIn vitro (cells)Efficacy outcome

    In HUVEC and C2C12 cells, pretreatment with SS31-LP reduced apoptosis in response to oxidative stress from H2O2 or blue LEDs.

    In plain wordsIn lab tests on cells, pretreatment with the SS31 liposome reduced cell death under oxidative stress.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseApoptosis under oxidative stress
    Study

    n: not reported in source

    HUVEC and C2C12 cells
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with SS31-LP enhanced cellular viability, mitigated oxidative damage, and reduced apoptosis in response to oxidative stress caused by H2O2 or blue LEDs.
    1 context sentence
    Summary · context
    The in vitro mitochondrial localization, cytotoxicity, antioxidant potential, and anti-apoptotic efficacy of SS31-LP were evaluated in HUVECs and C2C12 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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