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Study · In vitro (cells) · 2025

1 result

The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure.

Liu Y, Yi R, Zhang X, Sun X, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G

Ecotoxicology and environmental safety17 Apr 2025Cited by 5 (Europe PMC)

PMID40249973 (opens in a new tab)DOI10.1016/j.ecoenv.2025.118202 (opens in a new tab)PepBankPUB-40249973
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In renal cells exposed to patulin, SS‑31 significantly attenuated the onset of necroptosis.

    In plain wordsIn cells, SS‑31 reduced kidney-cell death caused by the toxin patulin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePatulin-induced necroptosis
    Study

    n: not reported in source

    MPC-5 cells
    Comparator
    Patulin without SS-31
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, the pharmacological protection of mitochondrial function by SS-31 significantly attenuated the onset of PAT-induced necroptosis.
    2 context sentences
    Summary · context
    This observation was also confirmed in MPC-5 cells.
    Summary · context
    In vitro, pretreatment with Nec-1 (a specific inhibitor of necroptosis) or si-STAT3 resulted in a significant reduction in necroptosis and improved mitochondrial dysfunction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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